Cholinergic Agents -Therapeutics

Question 1

Types of cholinoreceptors

Answer 1

Nicotinic
Muscarinic

Question 2

Subtypes of Nicotinic receptors

Answer 2

Nm, Nn

Question 3

Subtypes of Muscarinic receptors

Answer 3

M1, M2, M3, M4, M5

Question 4

Define Parasympathomimetic

Answer 4

mimic acetylcholine; cholinergic; muscarinic agonists

Question 5

Define Parasympatholytic

Answer 5

blocks acetylcholine; anticholinergic; muscarinic antagonists

Question 6

Contrast Parasympathomimetic direct and indirect agonists

Answer 6

direct- activates cholinoreceptors
indirect- stimulates acetylcholine release; inhibits acetylcholinesterase (AChE)

Question 7

What are the parasympatholytic actions?

Answer 7

-direct or indirect
-anticholinergic side-effects

Question 8

What are the direct acting Choline esters?

Answer 8

ACh
Methacholine
Carbachol
Bethanechol

Question 9

What are the direct acting Alkaloids?

Answer 9

Muscarine
Pilocapine

Question 10

What are the reversible AChE inhibitors?

Answer 10

Edrophonium
Physostigmine
Neostigmine

Question 11

What are the Irreversible AChE inhibitors?

Answer 11

Organophosphates

Question 12

Why are antimuscarinic drugs contraindicated in glaucoma?

Answer 12

Pilocaprine, M3 agonist
-works to facililatate outflow of aqueous humor and decrease intraocular pressure by contracting the Ciliary muscle

Question 13

What are the side effects of Muscarinic Receptor Agonists?

Answer 13

DUMBBELS
Diarhhea, Urination, Miosis, Bradycardia, Bronchoconstriction, Emesis, Lacrimation,(PSNS) Salivation + Sweating (SNS)

Question 14

What are the Gq muscarinic agonists?

Answer 14

M1, M3, M5

Question 15

What are the Gi muscarinic agonists?

Answer 15

M2, M4