Endocrine System Flashcards
What type of drugs end in “teride” such as Finasteride, Dutasteride?
5a-Reductase Inhibitors (antiandrogens)
-treat Benign Prostatic Hyperplasia, Male pattern baldness
What class do Spironolactone and Cyproterone belong to?
Steroidal Androgen Receptor inhibitors (antiandrogens)
-hirsutism in women, acne, excessive sexual drive in men
What do drugs that end in “tamide” belong to such as Flutamide, Enzalutamide?
Non-steroidal androgen receptor inhibitors
-prostate cancer
What are the SERM drugs?
Tamoxifen, Toremifene, Ospemifene, Raloxifene, Bazedoxifene, Clomiphene, Fulvestrant (SERD)
What is Clomiphene used for?
Polycystic ovary syndrome, anovulation and fertility, Gonadotropin-dependent ovarian hyperadrogenism
What is Raloxifene used for?
prevents osteoporsis in post-menopausal women; decreases risk for breast cancer
What are the side effects of androgen-like progestins?
Acne, Hirsutism, Weight Gain
What are the physiologic effects of progesterone?
causes the maturation of the endometrium following ovulation, causes a decrease in Na reabsorption, Promotes glycogen storage in the liver, increases basal insulin levels and the insulin response to glucose
What are some drug interactions with progestins(oral contraceptives)?
other steroids (glucocorticoids)
Anticonvulsants
Antibiotics
What are the posterior pituitary hormones?
Oxytocin and ADH (vasopressin)
What are the anterior pituitary hormones?
GH, TSH, ACTH, LH, FSH, PRL (prolactin)
What are the Hypothalimic hormones?
GHRH, SST (somatotropin), TRH, CRH, GnRH
What class of drugs end in “relix” such as Ganirelix, Cetrorelix, Abarelix, Degarelix?
GnRH receptor antagonists
-prostate cancer and control ovarian hyperstimulation syndrome
Which NSAIDs are not suitable for longer term use?
Indomethacin, Ketorlac
