Methylprednisone Flashcards
0
Q
CLASSIFICATION
A
CORTICOSTEROID / ANTI-INFLAMMATORY
1
Q
BRAND NAME
A
SOLUMEDROL
2
Q
MECHANISM OF ACTION
A
- DIFFUSES ACROSS THE CELL MEMBRANE
- BIND TO DNA
- REGULATES GENE EXPRESSION
- INC. SYNTHESIS OF PROTEINS & ENZYMES THAT INHIBIT INFLAMMATORY AGENTS (CYTOKINES, INTERLEUKIN, INTERFERON)
- INHIBITS SYNTHESIS OF PRO-INFLAMMATORY ENYMES
- IS AN IMMUNOSUPRESSANT
3
Q
PHARMACOKINETICS
A
ONSET: 2 - 6hr
PEAK: 4 - 8days
DURATION: 1 - 5 weeks
1/2 LIFE: 3.5hr
4
Q
INDICATIONS
A
- SEVERE ANAPHYLAXIS
- ASTHMA, COPD
- SPINAL CORD INJURY
5
Q
CONTRAINDICATIONS
A
NONE
6
Q
SIDE EFFECTS
A
- FLUID RETENTION
- CHF
- HTN
- ABD. DISTENTION
- VERTIGO
- HA
- NAUSEA
- MALAISE
- HICCUPS
7
Q
DOSEAGE
A
ASTHMA / ANAPHYLAXIS (ADULT): 125 - 250mg (IV, IO,)
SPINAL CORD INJURY (ADULT): 30mg/kg (IV, IO) over 15min, maintenance 5.4 mg/kg/hr for 24 - 48hr
ASTHMA / ANAPHYLAXIS (PEDI): 2mg/kg (IV, IO, IM) MAX DOSE 80mg
8
Q
PRECAUTIONS
A
- GIVE ONLY ONE DOSE PREHOSPITAL
- LT STEROID CAN CAUSE:
- GI BLEEDING
- PROLONGED WOUND HEALING
- SUPPRESSION OF ADRENOCORTICAL STEROIDS
9
Q
DRUG 2 DRUG INTERACTIONS
A
- LASIX AND ANTI-DIRUETICS INC. POTASSIUM LOSS
- DECREASED EFFECTS WITH PHENYTOIN, PHENOBARBITAL, AND RIFAMPIN DUE TO INC. METABOLISM OF STEROIDS.
