Diphenhydramine Flashcards
0
Q
CLASSIFICATION
A
Anti-Histamine
1
Q
BRAND NAME
A
Benadryl
2
Q
MECHANISM OF ACTION
A
Nonspecific competitive H1/H2 antagonist:
- Blocks histamine release
- Suppresses central cholinergic activity
- Inhibits reuptake and storage of Dopamine
- Leads to prolonged action of Dopamine
- Reduction of bronchoconstriction
- Vasodilation & inc. vascular permeability
3
Q
PHARMACOKINETICS
A
ONSET: 10 - 15min (IV), 15 - 30min (PO)
PEAK: 1 - 4hr
DURATION: 6 - 8hr
1/2 LIFE: 1 - 4hr
4
Q
INDICATIONS
A
- ALLERGIC REACTIONS
- ANAPHYLAXIS
- DYSTONIC REACTIONS DUE TO PHENOTHIAZINE ADMINISTRATION (EPS)
5
Q
CONTRAINDICATIONS
A
- HYPERSENSITIVITY
- ASTHMA
- NURSING MOTHERS
6
Q
SIDE EFFECTS
A
- SEDATION
- DRIES BRONCHIAL SECRETIONS
- BLURRED VISION
- HA
- PALPITATIONS
- DIZZINESS
- DROWSINESS
- FATIGUE
- EUPHORIA
7
Q
DOSEAGE
A
(ADULT) 25 - 50mg (IV, IO, IM, PO)
(PEDI) 1mg/kg (IV, IO, IM, PO) MAX DOSE 50mg
8
Q
PRECAUTIONS
A
- CAUTION PT’S WITH SEVER LIVER DISEASE
- ASTHMA
- NARROW ANGLE GLAUCOMA
- BPH
- MAY CAUSE HYPOTENSION
9
Q
DRUG 2 DRUG INTERACTIONS
A
POTENTIATES SEDATIVE EFFECTS OF:
- ALCOHOL
- BENZOS
- NARCOTICS
- TCA’s
- MAOI’s
- FUROSEMIDE
- ANTI - HTN’s
