Lorazepam Flashcards
0
Q
CLASSIFICATION
A
Anticonvulsant / Sedative / Hypnotic / Benzodiazepine
1
Q
BRAND NAME
A
ATIVAN
2
Q
MECHANISM OF ACTION
A
Positive allosteric modulator for GABAa receptors ~>
- Binds to benzo receptor site on chloride channels
- Potentiates binding & effects of GABA
(inc. intracellular Cl concentration leading to hyperpolarization of the cell)
3
Q
PHARMACOKINETICS
A
ONSET: 1 - 5min (IV), 15 - 30min (IM)
PEAK: 15 - 20min (IV), 2hr (IM)
DURATION: 6 - 8hr
1/2 LIFE: 10 - 20hr
4
Q
INDICATIONS
A
- MAJOR MOTOR SEIZURES
- PRE-MED FOR CARDIOVERSION
- ACUTE ANXIETY
5
Q
CONTRAINDICATION
A
HYPERSENSITIVITY
6
Q
SIDE EFFECTS
A
- HYPOTENSION
- DROWSINESS
- HA
- AMNESIA
- RESP. DEP.
- BLURRED VISION
- N+V
7
Q
DOSEAGE
A
(ADULT) 0.5 - 2mg (0.1mg/kg) IV,IO
(ADULT) 1 - 4mg (IM)
(PEDI) 0.05mg/kg (IV,IO)
8
Q
PRECAUTIONS
A
HAVE BENZO ANTAGONIST AVAILABLE
9
Q
DRUG 2 DRUG INTERACTIONS
A
Additive effects with:
- CNS depressants
- Alcohol