Lorazepam Flashcards

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0
Q

CLASSIFICATION

A

Anticonvulsant / Sedative / Hypnotic / Benzodiazepine

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1
Q

BRAND NAME

A

ATIVAN

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2
Q

MECHANISM OF ACTION

A

Positive allosteric modulator for GABAa receptors ~>

  • Binds to benzo receptor site on chloride channels
  • Potentiates binding & effects of GABA
    (inc. intracellular Cl concentration leading to hyperpolarization of the cell)
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3
Q

PHARMACOKINETICS

A

ONSET: 1 - 5min (IV), 15 - 30min (IM)
PEAK: 15 - 20min (IV), 2hr (IM)
DURATION: 6 - 8hr
1/2 LIFE: 10 - 20hr

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4
Q

INDICATIONS

A
  • MAJOR MOTOR SEIZURES
  • PRE-MED FOR CARDIOVERSION
  • ACUTE ANXIETY
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5
Q

CONTRAINDICATION

A

HYPERSENSITIVITY

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6
Q

SIDE EFFECTS

A
  • HYPOTENSION
  • DROWSINESS
  • HA
  • AMNESIA
  • RESP. DEP.
  • BLURRED VISION
  • N+V
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7
Q

DOSEAGE

A

(ADULT) 0.5 - 2mg (0.1mg/kg) IV,IO
(ADULT) 1 - 4mg (IM)
(PEDI) 0.05mg/kg (IV,IO)

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8
Q

PRECAUTIONS

A

HAVE BENZO ANTAGONIST AVAILABLE

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9
Q

DRUG 2 DRUG INTERACTIONS

A

Additive effects with:

  • CNS depressants
  • Alcohol
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