Epinepherine

Question 0

CLASSIFICATION

Answer 0

SYMPATHOMIMETIC, SYMPATHETIC AGONIST, CATECHOLAMINE

Question 1

BRAND NAME

Answer 1

ADRENALIN, EPI-PEN, EPI-PEN JR

Question 2

MECHANISM OF ACTION

Answer 2

• ALPHA1 AGONIST -> PERIPHERAL VASOCONSTRICTION, INC. SVR AND BP
• BETA1 AGONIST -> POS. INOTROPY, CHRONOTROPY, DROMOTROPY
• BETA2 AGONIST -> BRONCHODILATION
• BLOCKS DESTRUCTION OF MAST CELLS (WHICH RELEASE HISTAMINE) IN ANAPHYLAXIS

Question 3

PHARMACOKINETICS

Answer 3

ONSET: < 2min IV, 3- 10min IM
PEAK: < 5min IV, 20min IM
DURATION: 5 - 10min IV, 20 - 30min IM
1/2 LIFE: 5min IV

Question 4

INDICATIONS

Answer 4

• CARDIAC ARREST
• ANAPHYLAXIS / SEV. REACTIVE AIRWAY DISEASE / ASTHMA
• SYMPTOMATIC BRADYCARDIA / HYPOTENSION

Question 5

CONTRAINDICATIONS

Answer 5

• HTN
• TACHY - DYSRHYTHMIAS
• USE CAUTION WITH PREGNANCY AND CAD

Question 6

SIDE EFFECTS

Answer 6

ANXIETY, HA, DYSRHYTHMIAS, DIZZINESS, N + V

* LEADS TO INC. MYOCARDIAL OXYGEN DEMAND

Question 7

DOSEAGE

Answer 7

CARDIAC ARREST
(adult) 0.5 - 1.0mg IV, IO [1:10,000] q 3 - 5min
(pedi) 0.01mg/kg IV, IO [1:10,000] q 3 - 5min
BRADYCARDIA / HYPOTENSION
(adult) 2 - 10 micrograms / min
ANAPHYLAXIS / ASTHMA
(adult) 0.3 - 0.5mg IM, SC [1:1000] -> 0.1mg [1:10,000] slow IV over 3min
(pedi) 0.01mg/kg IM, SC [1:1000] -> 0.01mg/kg [1:10,000] slow IV over 3min (max dose = 0.3mg)

Question 8

PRECAUTIONS

Answer 8

SHOULD BE PROTECTED FROM LIGHT

Question 9

DRUG 2 DRUG INTERACTIONS

Answer 9

pH DEPENDENT, DEACTIVATED BY ALKALINE SOLUTIONS; EFFECTS INTERFERED WITH PT’S TAKING ANTIDEPRESSANTS, REACTS WITH CaCl2 & NaCO3 to PPT IN IV TUBING