Aspirin Flashcards
0
Q
CLASSIFICATION
A
PLATELET AGGREGATION INHIBITOR / ANTI-INFLAMMATORY
1
Q
BRAND NAME
A
BAYER
2
Q
MECHANISM OF ACTION
A
- INHIBITS PLATELET AGGREGATION BY BLOCKING THE FORMATION OF THROMBOXANE A2 -> THROMBOXANE A2 CAUSES PLATELET AGGREGATION AND ARTERIAL CONSTRICTION.
- COX INHIBITOR -> INHIBITS PROSTAGLANDIN SYNTHESIS AND REDUCES SPREAD OF INFLAMMATION.
3
Q
PHARMACOKINETICS
A
ONSET: 5 - 30min
PEAK: 15 - 120min
DURATION: 1 - 4hr
1/2 LIFE: 15 - 20min
4
Q
INDICATIONS
A
NEW ONSET CHEST PAIN SUGGESTIVE OF AMI / ACS
5
Q
CONTRAINDICATIONS
A
HYPERSENSITIVITY, RELATIVELY CONTRAINDICATED WITH ACTIVE ULCER DISEASE AND ASTHMA
6
Q
SIDE EFFECTS
A
GI BLEEDING, WHEEZING, N + V, HEARTBURN, PROLONGED BLEEDING
7
Q
DOSEAGE
A
ADULT: 160 - 325mg PO (81mg baby aspiring preferred because it can be chewed and swallowed)
PEDI: NOT RECOMMENDED
8
Q
PRECAUTIONS
A
GIVING DOSES HIGHER THAN RECOMMENDED CAN INTERFERE WITH POSSIBLE BENEFITS, USE ENTERIC COATED PILLS WITH PT’S WITH HISTORY OF GI BLEED
9
Q
DRUG 2 DRUG INTERACTIONS
A
- ASPIRIN + OTHER ANTI-INFLAMMATORY AGENTS = ADDITIVE EFFECTS
- ASPIRIN + ANTACID -> DECREASES BLOOD LEVELS OF DRUG BECAUSE IT DECREASES ABSORBTION
