Metabolism of Nucleotides Flashcards
1
Q
What is the difference between a nucleotide and a nucleoside?
A
A nucleotide has one phosphate, whereas a nucleoside has none
2
Q
What enzyme(s) catalyze the conversion of nucleic acid to nucleotides?
A
Nucleases/phosphoesterases
3
Q
What major coenzymes are nucleotides a part of?
A
NAD, FAD, and CoA
4
Q
What are the precursors for purine nucleotides?
A
Ribose-5-P, aspartate, glycine, glutamine, formate, and CO2,
5
Q
What is PRPP and how is it made?
A
Phosphoribosylpyrophosphate;it is made by adding on a pyrophosphate to ribose; it activates the ribose because it is an excellent leaving group, so the nitrogenous base will be able to be added on
