Activators and Inihibitors Flashcards
Activator of pyruvate carboxylase?
Acetyl-CoA
Activators of glucose 6-phosphate dehydrogenase?
NADP+
Activators and inhibitors of hexokinase?
glucose 6-phosphate is an inhibitor; no activators
Activators and inhibitors of PFK-1?
Activators: AMP, Fructose 2,6-Bisphosphate
Inhibitors: ATP, Citrate
Activators and inhibitors of Pyruvate Kinase?
Activators: Fructose 1,6-Bisphosphate
Inhibitors: ATP, Acetyl-CoA, Fatty Acids
what are hormonal effects regulated by in glycogenlysis?
cAMP
Activators and Inhibitors of Glycogen Phosphorylase?
In muscle:
Inhibitors: ATP and Glucose-6-Phosphate
Activators: AMP
Liver:
Inhibitor: Glucose
Activators and Inhibitors of Glycogen Synthase?
In both muscle and liver:
Glycogen synthase “b” is activated by glucose-6-phosphate
In the liver (?): insulin inactivates GS
What activates phosphorylase kinase?
Calcium
What inactivates GSK-3
Insulin
What activates Protein phosphorylase 1?
Insulin
Activators and inhibitors of PDH
Activators: ADP, Pyruvate, and NAD+
Inhibitors: NADH, ATP, Acetyl-CoA
Activators and Inhibitors of isocitrate dehydrogenase?
Activators: ADP
Inhibitors: NADH, ATP
Activators and Inhibitors of alpha-ketoglutarate dehydrogenase complex?
Activators: none
Inhibitors: ATP, NADH, succinyl-CoA
Inhibitors of Complex I?
Electron transfer to ubiquinone (Q) blocked by rotenone and amytal
