Metabolism in Exercise Flashcards
Kaul 1. Distinguish between PFK2 regulation in liver versus muscle. 2. Explain the role of acetyl CoA carboxylase (ACC-2) in fatty acid oxidation in muscle. 3. Explain the role of the alanine cycle during exercise. 4. Explain the role of AMPK in muscle metabolism. 5. Describe the three energy systems used in muscle. 6. Describe which energy system is used for different types of exercises and the biochemical reasoning for these choices. 7. Explain the reasoning behind the use of different fuels
Muscle does not express ______ activity or _____ receptors.
Glucose-6-Phosphatase, Glucagon
During Alcohol consumption, the buildup of NADH from the creation of acetaladehyde and acetyl-coA through DHs, it inhibits _____ and causes buildup of lactate
PDH
AMPK inhibits ACC2, resulting in less Malonyl-CoA and ultimately more _____
Beta Oxidation
The buildup of NADH inhibits TCA enzymes _____ and _____, and promotes the backward conversion of Oxaloacetate into Malate
Isocitrate dehydrogenase , a-ketoglutarate DH
Lactate, G3P, and Malate are all favored in EtOH metabolism because _____ ratio is increased
NADH/NAD
_____ is a Cofactor for Pyruvate Dehydrogenase, so for a hypoglycemic Wernicke’s Alcohol Syndrome patient, you would need to supplement with _____ first and not just give glucose, because that would further aggravate the lactic acid accumulation
Thiamine
Unlike regular PFK-2, The Muscle’s PFK-2 FBPase-2 activity is _____ inactivated due to a different Serine; ultimately leading to Mega Glycolysis always occurring
Always
_____ makes Malonlyl CoA in the muscle to inhibit Carnitine Palmitoyl Transferase I (CPT-1) and ultimately inhibit B-oxidation.
Acetyl CoA Carboxylase 2 (ACC2)
The Alcohol pathway is EtOH—ADH–>Acetaldehyde—-ALDH—–>Acetyl CoA. Therefore, too much _____ or Too little _____ can cause a buildup of Acetaldehyde.
ADH, ALDH
Disulfiram inhibits _____ and causes a buildup of Acetaldehyde, resulting in nausea
ALDH
