Diabetes Mellitus

Question 1

Acarbose is an alpha-_____ inhibitor

Answer 1

Glucosidase

Question 2

Incretins such as _____ or _____ increase insulin during the Anticipatory rise

Answer 2

GLP-1, GIP

Question 3

Biguanides (Metformin) inhibit Complex _____ of the ETC, thus decreasing ATP and increasing AMP to inhibit Gluconeogenic enzymes like F1,6BPase and stimulates AMPK to turn on ATP/Glycolytic pathways and shut of Gluconeogenic (avoid high blood sugar)

Answer 3

I

Question 4

Because of lack of Insulin in Type I diabetics, _____ levels are low and Triglys go up!

Answer 4

LPL

Question 5

DPP-4 Inhibitors (Januvia) enhance incretin levels by inhibiting the degradative enzyme _____, to allow them to work in a glucose-dependant manner

Answer 5

DPP-4

Question 6

Leptin and Adiponectin _____ the activity of Insulin

Answer 6

Promote

Question 7

Resistin ____ the activity of insulin

Answer 7

Inhibits

Question 8

Ketosis is most common in type _____ diabetes

Answer 8

I

Question 9

Type ___ Diabetes has a much stronger Genetic predispostion than ____ Diabetes

Answer 9

II, I

Question 10

Sulfonylurea drugs (Gliburide) close ____ channels to promote insulin release, Independent to glucose

Answer 10

K+