Metabolic Pathways Flashcards

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1
Q

Metabolic pathways are

A

integrated and controlled reactions within a cell

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2
Q

Metabolic pathways are reactions controlled by

A

presence or absence of enzymes which act as catalysts

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3
Q

In animals, specific metabolic pathways can produce

A

vitamins and haemoglobin

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4
Q

Metabolic pathways are a series of reactions that

A

start with a substrate

finish with end product

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5
Q

Anabolic

A

requires energy

build up large molecules from smaller ones (biosynthesis)

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6
Q

Catabolic

A

releases energy

break down large molecules into smaller ones (degradation)

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7
Q

example of anabolic reaction

A

synthesis of glycogen from glucose

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8
Q

example of catabolic reaction

A

process of food digestion, where different enzymes break down food particles so they can be absorbed by small intestine

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9
Q

Metabolic pathways can be

A

reversible and irreversible

most are reversible

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10
Q

All metabolic pathways have to be regulated and controlled to…

A

Stop build up of an end products that isnt needed

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11
Q

Active site has

A

high affinity to substrate as well as being specific to substrate, this orientates reactants into correct position for reaction to take place

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12
Q

Binding of enzyme to substrate does what?

A

lowers activation energy of reaction

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13
Q

rate of enzyme reaction can be affected by?

A

substrate concentration

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14
Q

As substrate concentration increases

A

enzyme reaction increases until all active sites are occupied by substrates, then all active sites are occupied, enzyme is saturated

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15
Q

When all active sites are occupied, the enzyme is said to be?

A

Saturated

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16
Q

At point of saturation, adding more substrates…

A

Makes no difference to reaction rate

17
Q

Inhibitors

A

can be used to stop enzyme binding to substrate - as a result inhibitors can directly control progress of metabolic pathway

18
Q

3 types of inhibition

A

Competitive
Non-competitive
Feedback

19
Q

Competitive Inhibition

A

Occurs when an inhibitor molecule binds to active site of enzyme

Stops substrate from binding

compete with substrate because have similar molecular shape

20
Q

How to reverse competitive inhibition

A

Increase substrate concentration

Substrate eventually dilutes inhibitor so all enzyme molecules bind to substrate

21
Q

Example of competitive inhibitor

A

Sarin

22
Q

Non-competitive inhibition

A

An inhibitor does not bind to active site bit binds to a different part of enzyme, this changes the active site shape, this stops substrate binding to enzyme and decreases reaction rate

23
Q

Example of non-competitive inhibitors

A

cyanide, mercury or silver

24
Q

Graph of inhibitors

A

Steep and high - no inhibitor

slower but same end height - competitive inhibitor

slower and lower - competitive inhibition

25
Q

Feedback inhibition

A

End product in a metabolic pathway binds to an enzyme at start of pathway

26
Q

Negative feedback process

A

Stops metabolic pathway and so prevents further synthesis of end product until end product concentration decreases. Higher concentration of end product, quicker metabolic pathways stops