Controlling Fertility Flashcards
Fertility
Ability to produce offspring
Continuous Fertility
Male
Levels of FSH and ICSE are kept relatively constant through negative feedback. As a result, sperm are produced continually.
Cyclical Fertility
In women, fertility is cyclical. Levels of oestrogen and progesterone, FSH and LH fluctuate. As a result women are only fertile for small number of days before and after ovulation during each menstrual cycle.
Ovulation
Release of an ovum from one of ovaries
Identifying women’s fertile period
body temperature - increases after ovulation
cervical mucus - clearer, wetter and more slippery
timing of menstrual cycle - ovulation occurs 10 to 16 dayys before start of period
stimulating ovulation
Prevent negative feedback effect of oestrogen on FSH
Mimic normal action FSH and LH, stimulating ovulation
Artificial stimulation ovulation can lead to….
multiple births - super ovulation
can be used un IVF too to help collect ova as several need to be collected
AI may be useful when?
man has a low sperm count
couple are unable to have vaginal intercourse
condition means couple need help to conceive
when donor sperm is being used by same-sex couple or when a man in mixed-sex couple is sterile
Sperm sample AI
A sample of sperm is treated to remove dead sperm, slow sperm and impurities. A concentrated sample of healthy sperm is then passed through a catheter into the uterus. A sperm donor may also be used in artificial insemination in cases of a male being sterile.
Intra cytoplasmic sperm injection used when
sperm count low
mature sperm are abnormally shaped or don’t move normally
sperm needs to be surgically removed
frozen sperm has reduced quality being used
ICSI sperm sample
Sperm collected and head of sperm drawn into needle and injected directly into egg in order to increase chances of fertilisation.
IVF can be used when
issues with sperm quality
womens blocked oviduct
where one or both partners may pass genetic condition
donor or sperm egg being used
IVF
Involves one or more eggs being removed from woman’s ovaries. These are then fertilised with sperm in laboratory
IVF steps
- the mother is given FSH and LH to stimulate maturation of several eggs in ovary
- egg are collected from mother and fertilised with sperm from father in culture dish in lab
- fertilised eggare incubated until they develop into embryos
- at stage when tiny balls of at least 8 cells, one or 2 embryos inserted into other’s uterus
develop of what has allowed IVF treatments to develop further
microscopy techniques
Pre-inplantation genetic diagnosis (PGD)
IVF is used in conjunction with PGD where one or more parents at risk of serious inherited disease to their children. PGD can be used to check single gene disorders and chromosome abnormalities in developing embryos before they are implanted.