Metabolic Integration Flashcards
What are the four things that Glucose-6-P can be converted to
- Glucose1-P for use in glycogen
- Glucose for release into the blood
- 6-phophogluconolactetone to generate NADPH by pentose phosphate pathway
- fructose-6-P, used in glycolytic pathway to produce pyruvate
What does creatine kinase do
catalyzes a reversible transfer reaction that generates ATP in muscle cells that is a source of energy for muscle contraction
What is resynthesized during the muscle recovery period
Phosphocreateine
The brain depends on ___ as its sole energy source
glucose
what is the function of astrocytes
in the brain transport glucose metabolites to surrounding neruons
what is hte main cite for PET imaging
Glucose in the brain
What is the main export in the liver
glucose and triaglycerols
triacylglycerols in the blood are hydrolyzed by what
LPL- lipoprotein lipase
T or F: amino acids, ketone and lactate are at high levels in the blood
F
what does the traicylglycerol cycle do
exchanges free fatty acids and triacylglycerols between adipose and liver cells
Where does the glycernogenic pathway function
apidoctes and hepatocyctes
Insulin and glucagon are ____ hormones produced in the ______ that control ______
peptide homrones produced in the pancreas and control glucose homeostasis
what secretes insulin in the pancreas
islets of Langerhans in beta cells
where is glucagon secreted
islets of langerhans in alpha cells
what do delta cells produce
somatostatin which controls the seceretory process
what do acinar cells synthesize
digestive enzymes
Insulin signaling in the brain activates signals that regulate ____
eating behaviour
what are the three key differences in insulin effects in lever vs muscle
- GLUT4 in skeletal, GLUT2 in pancreas
- skeletal muscles do not contain Glucose-6-p and fatty acid synthase so all glucose is used for metabolic fuel
- Mass of skeletal muscle 30x grater than liver, therefore insulin stimulation of glucose uptake in muscle is hte primary mechanism
activation of glucagon receptors in liver and adipose tissues incerases, what also increases to activate pKA
cAMP