METABOLIC DISORDERS - ACUTE PORPHYRIAS Flashcards
1
Q
what is acute prophylaxis
A
hereditary disorder of haem biosynthesis
2
Q
how many people is affected by acute prophyrias
A
1 in 75000
3
Q
what can induce acute porphyric crisis
A
- certain drugs
- if no alternate / drug tx for serious conditions don’t stop
4
Q
what is tx of moderate - severe acute porphyria crisis
A
IV haem arginate
5
Q
which drugs cause acute porphyrais?
A
amiodarone, carbamazepine, chloramphenicol, clindamycin, diltiazem, erythromycin, indapamide, isoniazid, mefenamic acid, methyldopa, nitrofurantoin, phenytoin, rifampicin, risperidone, spironolactone, tamoxifen, topiramate, trimethoprim, valproate, verapamil
