Mehl. PED file bullets in general that didnt know nr 1 Flashcards

1
Q

8M + recently convalesced from URTI + now has stridor + fever 101F; Dx? how to make Dx?

A

usually S. aureus;
Dx w/ bronchoscopy;

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2
Q

8M + recently convalesced from URTI + now has stridor + fever 101F; Tx?

A

Tx with third-gen cephalosporin + aminopenicillin (e.g., IV flucloxacillin).

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3
Q

8-month-old girl + stridor that improves with neck extension; Dx?

A

vascular ring

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4
Q

8-month-old girl + stridor that improves when prone or upright; Dx?

A

laryngomalacia

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5
Q

3F + 2-wk Hx of cough and nasal congestion + snoring loudly past 6 months + P/E shows she breathes predominantly through her mouth + 1/6 holosystolic murmur and loud S2 + CXR shows cardiomegaly + increased pulmonary vascular markings + echo shows RV hypertrophy and mild tricuspid regurg; what is the most appropriate long-term Mx for this patient?

A

adenoidectomy and tonsillectomy

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6
Q

12M + steatorrhea + recurrent URTIs + new-onset stridor; why the new-onset stridor?

A

nasal polyps (common in cystic fibrosis); steatorrhea due to exocrine pancreas insufficiency.

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7
Q

7F + painless lateral neck mass over sternocleidomastoid; Dx?

A

brachial cleft cyst.

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8
Q

Neonate born by forceps delivery + crooked neck + 1.5cm mass palpated in left side of neck; Dx?

A

“sternomastoid injury.”

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9
Q

7M + one-week Hx of low-grade fever and fatigue + 3-day Hx of rash and swelling starting at ankles and spreading upward + ankles tender + exam shows “several palpable petechiae and confluent purpuric areas over lower extremities”; Dx? Tx?

A

Henoch-Schonlein purpura.
Can present with tetrad of 1) palpable purpura (and apparently petechiae), 2) IgA nephropathy (red urine), 3) abdominal pain (mesenteric adenitis), and 4) arthralgias; classically following viral infection, however 2CK vignettes will often omit mentioning the infection altogether; self-limiting.

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10
Q

4-month-old girl + asplenia + dextrocardia; which antibiotic should be used for prophylaxis? Dx?

A

penicillin (most important for Strep pneumo due to asplenia);

Dx is Ivemark syndrome (dextrocardia/situs inversus + hypoplasia of various organ systems).

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11
Q

12-month-old female + sickle cell + missed dose of penicillin prophylaxis + now has sepsis; which Abx to give?

A

answer = cefotaxime; wrong answers are penicillin and ceftriaxone.

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12
Q

Neonate with APGARs good at birth + 3-10 days later has BP 60/35 in upper extremities and unobtainable in lower extremities + O2 sats 98 mmHg but nails appear dusky + 3/6 holosystolic murmur at left sternal border; Q asks what’s responsible for current presentation?

A

answer = “closure of ductus arteriosus”

Dx = preductal coarctation (the type seen in neonates); CoA can be associated with tricuspid regurgitation and other cardiac abnormalities. Dusky nailbeds don’t equate to cyanosis if O2 sats are normal.

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13
Q

Neonate + pulmonary valvular stenosis; Dx?

A

Noonan syndrome; second most common
syndrome associated with congenital heart disease after Down.

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14
Q

14F + Down syndrome + polycythemia + moderate cyanosis and digital clubbing + no murmur on cardio exam but loud S2 + echo shows large VSD and dilated main pulmonary artery; mechanism for polycythemia?

A

answer on Peds NBME = pulmonary artery hypertension”;

Dx is Eisenmenger (large VSD with reversal RàL); large VSDs may present without murmur; pulmonary vessels constrict to compensate for high preload from previous L->R VSD shunt; constriction leads to hypoxia and secondary polycythemia with high EPO; should also be noted that Down syndrome is associated with endocardial cushion defects (AVSD > VSD > ASD; Step 1).

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15
Q

Neonate born vaginally at 43 weeks gestation + cyanotic + pO2 is 26mmHg on 100% oxygen + CXR normal + echo shows normal cardiac anatomy with a right-to-left shunt across the foramen ovale; what is the mechanism for the child’s condition?

A

“failure of pulmonary vasodilation”à Dx = persistent fetal circulation (aka persistent pulmonary hypertension of the newborn).

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16
Q

Three ways VSD sounds on Peds shelf?

A

Holosystolic murmur at left sternal border PLUS either parasternal heave or palpable thrill.

Holosystolic murmur at left sternal border PLUS left atrial enlargement (LàR shunt leads to increased preload back to LA in addition to the systemic preload).

Holosystolic murmur at left sternal border PLUS diastolic rumble (volume overload of LA).

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17
Q

3M + elfin-like facies + hypercalcemia + well-developed verbal skills; Dx?

what heart problems?

A

William syndrome.

Heart problem in William syndrome supravalvular aortic stenosis.

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18
Q

10-month-old girl + sore throat for 2 days + fever 101F + S3 gallop heard on auscultation; what best explains these findings?

A

myocarditis (rheumatic fever); should be noted that PSGN will take 1-2 weeks to occur after Group A Strep infection, but NBME has RF occurring as early as 2 days after the Strep pharyngitis; type II hypersensitivity via molecular mimicry with Group A Strep M
protein (Step 1); Tx with penicillin.

19
Q

8M + sore throat + new-onset tic; Dx?

A

answer = PANDAS (Pediatric Autoimmune Neuropsychiatric
Disorder Associated with Streptococcus)

Group A Strep infection can precipitate OCD, Tourette, ADHD; answer = “check Streptolysin O titers”;

20
Q

7F + facial grimaces past 5 months + no other motor findings or abnormal sounds + mental status normal; next best step in Mx? Dx?

A

schedule a follow-up examination in 3 months”

Dx = provisional tic disorder. 1/5 children experience some form of tic disorder; most common ages 7- 12; usually lasts less than a year; “watch and wait” approach recommended. Provisional tic disorder used to be called transient tic disorder; the name was changed because a small % go on to develop chronic tics.

21
Q

4F + spiking fever followed by a rash + no other findings; Dx?

A

roseola (HHV-6); all you need to remember is the “spiking fever followed by a rash.”

22
Q

6M + Q shows you two pics: one of a circular rash (not a target) on the forearm; the other pic is a Bell palsy (asymmetric smile); Q asks you to pick the antibiotic? Dx?

A

answer = amoxicillin;

Dx = Lyme disease; rash need not be target (erythema chronicum migrans); don’t give doxycycline to kids age <8.

23
Q

3M + rapid breathing for 1 hour + hyper-resonance on right side of chest + CXR shows overexpansion of right lung; next best step in Mx?

A

answer = “endoscopic examination of the patient’s airway” (bronchoscopy for foreign body aspiration); this Q is exceedingly HY for Peds shelf; easier Qs will mention a 14-month-old crawling around on the floor beforehand.

24
Q

6M + just diagnosed with ALL + parents don’t want him to know + you’re now alone with the kid and
he asked you if he’s going to die; what do you say?

A

“Have you talked to your parents about this?”

25
M + ALL + facial flushing and/or positive Pemberton sign; Dx?
answer = TALL (T cell ALL). a thymic lesion can lead to SVC-like syndrome.
26
12F + DKA + HR 56 + BP 146/88 + headache and confusion; Q asks cause of the mental status change?
cerebral edema; hyperglycemia leads to osmotic changes with water moving out of cells -> cerebral edema (serious complication of DKA) -> give IV normal saline first before adding insulin.
27
3F + two-week Hx of fever, pallor, and decreased appetite + mouth ulcers + RBCs, WBCs, and platelets all low; Dx? Tx?
answer = aplastic anemia (presumably from Parvo, but can also be other viruses); next best step = immediate IV antibiotics for neutropenic fever (any time you have low neutrophils in the setting of fever; if WBCs are low, then neutrophils also low; in addition, mouth ulcers on USMLE = hugely HY presentation of neutropenia).
28
4F + treated for three weeks with TMP/SMX + now has isolated neutropenia; cause of neutropenia?
answer = TMP/SMX just be aware this can cause neutropenia.
29
Bruton X-linked agammaglobulinemia) Tx?
“monthly infusion of immune globulin.”
30
3F + fever + RBCs, WBCs, platelets all low; IV antibiotics are administered; next best step in Dx?
answer = bone marrow aspiration (sounds overly invasive, but it’s what they want to Dx the aplastic anemia); there’s a UWorld Q where “Parvo IgM/IgG titers” is an answer, but it’s in an adult daycare worker with a lacy body rash and no drop in her hematologic cell lines.
31
4M + hypoplastic thumbs + RBCs, WBCs, platelets all decreased; Dx?
answer = Fanconi anemia; AR aplastic anemia characterized by absent or hypoplastic thumbs or radii.
32
4M + triphalyngeal thumbs + low RBCs; Dx?
Diamond-Blackfan anemia; pure red cell aplasia characterized by triphalyngeal thumbs.
33
16F + 3-day Hx of pain and pressure over left cheek + Hx of strep pneumonias at age 6 and 10 + seasonal allergies; Dx?
answer = “impaired humoral immunity” or “deficiency of mucosal immunoglobulin”; Dx is IgA deficiency (one of the highest yield presentations for not just the Peds shelf but also USMLE); sore cheek = sinusitis; presents as recurrent sinopulmonary infections; also associated with Hx of Giardia infection, autoimmune diseases (e.g., vitiligo), and atopy (dry cough in winter [cough-variant asthma], hay fever in spring, eczema in summer); anaphylaxis with blood transfusion is “too easy” for most 2CK IgA deficiency Qs but will rarely show up, yes.
34
6F + recurrent Staph abscesses + eczematoid skin lesions + abnormal dentition; Dx?
hyper IgE syndrome (Job syndrome) FATED = abnormal Facies, staphylococcal cold Abscesses, retained primary Teeth, hyper IgE, Dermatologic findings (e.g., eczematoid lesions).
35
12M + eczematoid skin lesion on forehead + nosebleeds + Hx of infections; Q asks which cell is dysfunctional?
answer = T cell (on student’s 2CK, not Step 1); Dx = Wiskott-Aldrich syndrome (XR) àclassic triad of eczematoid skin lesions + thrombocytopenia + immunodeficiency.
36
3M + recurrent OM + recently underwent placement of tympanostomy tube + mom HIV negative; Dx?
answer = “antibody deficiency” IgA deficiency.
37
6M + recurrent Staph infections + diarrhea; Dx?
answer = “neutrophil oxidation burst” chronic granulomatous disease (NADPH oxidase deficiency) infections with catalase (+) organisms (Staph infections are signature complication); SPACES = Staph, Psuedomonas, Aspergillus, Candida, E. coli, Serratia; Aspergillus most common fungal infection seen in CGD; 2CK has Q where child gets Serratia sepsis as part of CGD.
38
17M + 3-wk Hx of lymphadenopathy, fever, and loose stools + hepatosplenomegaly + low RBCs and WBCs + high IgM and IgG; Dx?
answer = HIV infection; Wrong = any immunodeficiency
39
8M + Q shows you a pic of a red dot on the tongue or nailbed; Dx?
hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu); autosomal dominant; HY tangent outside peds: should be noted that this can lead to pulmonary arteriovenous fistulae in adults with high-output cardiac failure (NBME for Step 1 has 45M + epistaxis since childhood + shows pic of red dot on tongue + high ejection fraction; answer = “pulmonary arteriovenous fistula” [due to HHT]).
40
Mother is HIV (+); what should be given to neonate following C-section?
answer = “A 6-week course of zidovudine (AZT) within 12 hours of delivery
41
6F + pruritic rash in intertriginous areas of elbows and knees + often appears with episodes of wheezing and respiratory distress; Tx?
answer on NBME = topical triamcinolone (steroid); Dx is atopic dermatitis (eczema) as part of atopy; should be noted “emollients” (lotion; should be oil-based) are tried before topical steroids if both are listed.
42
17M + 12-month Hx of intermittent swelling of face/lips, chest, and arms + during episodes has abdominal pain and diarrhea; next best step in Dx? Tx?
answer = “measurement of C1 esterase inhibitor concentration”; not C1 esterase; C1 esterase inhibitor; Dx = hereditary angioedema; acute Tx = C1 esterase inhibitor administration; danazol also used (induces liver to produce more C1EI).
43
For intussuception can be done UG (target sign), but on usmle enema is for both Dx and Mx.
how to Dx intussusception is always enema (Dx and therapeutic);