Medsci cardiovascular and endocrine Flashcards
What is the measure of the cardiac output?
The amount of blood ejected to the aorta per minute.
Frank starling law of the heart
The more stretched the ventricles are the more forceful the contraction, the more stretched the muscle fibers in the cardiac system the more forceful the contraction will be. This ensures the amount of blood returning via the venous system is matched by the amount leaving the heart: venous return = cardiac output.
the heart valves are regulated by the cardiovascular centre in the brainstem (true or false)
false
The neurotransmitter used in the parasympathetic system released from the post and pre ganglionic neuron is (ANS)
acetylcholine, only one type of neurotransmitter.
Sensory input for the somatic nervous system is the (also is this voluntary or involuntary?)
special senses and somatic senses and voluntary movement.
Does the autonomic nervous system consist of a single neuron pathway or two neuron pathway
it is a 2 neuron pathway from the preganglionic neuron in the CNS and the postganglionic neuron located in the ganglion and extends axon to the target organ
Neurotransmitter(s) used in the sympathetic nervous system
Acetylcholine and norepinephrine. Two types of neurotransmitter. Pre ganglionic: acetylcholine, post to effector: norepinephrine. Post ganglionic to sweat glands is acetylcholine.
Does the somatic nervous system require 2 neuron pathway or one.
Single neuron pathway directly from CNS to target muscle.
What are the neurotransmitters used in the somatic nervous system?
Acetylcholine
what is the autonomic nervous system
divided into two branches, the parasympathetic and the sympathetic nervous systems. Which each use different neurotransmitters. However in the parasympathetic nervous system, acetylcholine is the dominant neurotransmitter. Whereas in the sympathetic nervous system, norepinephrine and acetylcholine are used for both pre ganglionic and post ganglionic neurons.
What is the neurotransmitter used for all pre ganglionic axons, post ganglionic parasympathetic neurons and post ganglionic sympathetic neurons to sweat glands
acetylcholine
What is the neurotransmitter used for postganglionic sympathetic fibres to most effector tissues
norepinephrine.
What is unusual about the venous drainage of the gut
Blood leaving the gut does not directly return back to the heart as it carries deoxygenated blood to the liver which is transported through a portal system (hepatic portal vein). The liver also receives oxygenated blood from the systemic circuit(artery) meaning it has a dual blood supply.
Where does the left atrium receive oxygenated blood from
pulmonary vein
During ventricular ejection where does the left ventricle send the oxygenated blood
To the aortic arch (main artery) through the now opened aortic valves.
What is the valve in between the right ventricle and atria
tricuspid valve
What are the pulmonary and aortic valves classed as
semilunar valves with three cusps that have pockets to fill with blood in order to prevent backflow. These are closed during ventricular filling and open during ejection.
Where does the right atrium receive its deoxygenated blood
from the superior and interior vena cava
What is the valve associated with the right atrium and ventricle
tricuspid valve
Where does the deoxygenated blood flow from the right ventricle during ejection
blood goes through the pulmonary valve to the pulmonary trunk toward the lungs to be reoxygenated and returned to the left atrium via the pulmonary vein.
what prevents the valves from inverting in the cardiovascular structure of the heart?
The cordae tendinae which act like parachute strings.
What factors affect stroke volume?
Preload, afterload and the contractility of the heart.
The apex of the heart points
inferiorly and anteriorly (dorsal) and toward the left
the divisions of the heart corresponding to the midline of the body
1/3 of the heart is toward the right and 2/3 of the heart is toward the left
The right border of the heart is mainly formed by
the right atrium
the inferior border of the heart is mainly formed by the
right ventricle
the left border of the heart is mainly formed by
the left ventricle.
Functions of the fibrous skeleton
Insulates the ventricular myocardium from the electrical activity of the atria and also acts as structural support for the high pressure valves of the heart.
The protection of the heart and the spacing order of the parietal and visceral pericardium
The visceral pericardium is the innermost layer, and the parietal the outermost layer. The middle consists of the pericardial space.
Which valve is not supported by a fibrous ring/skeleton?
The pulmonary valve.
Ventricular filling
Longest phase of cardiac cycle, 80% capacity as mitral valve is open.
What is the function of SV node
Acts as the pacemaker of a heart which is independent to the nervous system, allowing the heart to produce it’s own electrical impulses stimulating its contraction, without neural input from the brain/and or spinal cord.
Function of AV node
Causes a delay of action potentials traveling through the muscle of the heart. This gives the atria extra time to contract as mechanical contraction is slower than electrical conduction. This allows the a top up of volume to the ventricles prior to contraction.
Without this the atrium and ventricles would contract simultaneously.
conduction potential pathway
SA node -> Atrial myocardium -> AV node -> AV bundle (of His) -> left right bundle branches -> purkinje fibres -> ventricular myocardium.
The cardiac cycle
Ventricular filling phase -> atrial contraction -> isovolumetric contraction -> ventricular ejection -> isovolumetric ventricular relaxation.
pressure in right atria
5mmHg peak pressure
Pressure in left atria
8mmHg
Pressure in aorta
120/90 mmHg
Pulmonary circuit blood volume
9%
systemic circuit blood volume
84%
blood volume in the pumps of the circuits
7%
Total output of blood volume from each pump
5L/min on each side.
Total blood volume in the pulmonary/systemic circuits and pumps
5L
Portal vein between the gut and liver
hepatic portal vein transports the nutrients from the gut to the liver
why is the liver different in terms of the systemic circuit organs
the liver has two areas of blood supply, deoxygenated blood from the hepatic portal vein to the liver from the gut and the systemic arteries that pump oxygenated blood to the liver
the systemic circuit blood pressure and resistance level
High pressure and resistance and consists of many systems
the pulmonary circuit blood pressure and resistance level
medium resistance and pressure and the pulmonary veins carry the oxygenated blood and arteries carry deoxygenated.
veins are low or high pressure
low
arteries are low or high pressure
high
interventricular sulcus
the sulcus that divides the two ventricles apart, usually surrounded by fat.
maximum pressure in the right ventricle
27 mmHg
right atrial catheterization
1929 Dr werner Forssmann
max pressure in the left ventricle
120mmHg
Papillary muscles
passsive structures that hold up the cordae tendineae in the ventricles.
Inlets diameter vs outlet
the inlets must be of larger diameter than the outlets because blood leaves the ventricles at high pressure. Inlets are large due to passive filling.
Apex of the heart
the opposite side of the base of the heart, pointed toward the left.
ventricular outlet valves
outlet valves are classed as semilunar valves with three cusps that can fill with blood. They are passive and dont require cordae tendineae or papillary muscles and are controlled by blood flow direction.
Wall thickness ration of the right ventricle vs left ventricle
3:1 diameter
peak pressure ratios comparing right and left ventricles
5:1
base of the heart
the highest point of the heart, superior border = blood vessels = base
Visceral pericardium
attached to the heart itself, the innermost layer of pericardium
fibrous pericardium
on top of the pericardium support parietal pericardium.
parietal pericardium,
outermost layer of pericardium on periphery.
pericardial space
filled with serous fluid allows two membranes to slide and reduce friction.
Mesothelial cells
forms the serous membrane
serous membrane
secretes serous fluid
Layers of the heart/around heart
fiborous pericardium, parietal pericardium, pericardial space, epicardium/visceral pericardium, myocardium, endocardium and inside the ventricle.
the layer of pericardium under myocardium
endocardium
SA node signals..
SA node depolarises and signals through wall of atrium, telling the myocardium to contract. This causes uniform and even contraction
SA node and cardiac myocytes/purkinje cells
act like nerves of the heart and conduct signals to tell the heart to contract. Modified cardiac muscle fibers
SA node -> atrial muscle speed and result
slow and causes even atrial contraction
AV node
very slow and causes 100 millisecond delay for the atria to top up the ventricles.
AV bundle -> purkinje fibres
fast and cause complete and even ventricular contraction -> systole.
ventricular filling phase
ventricle fills to about 80% of its capacity, long phase. Mitral valve opens quietly. 5mmHg in left atrium and 90mmHg in aorta.
SA node can be affected by
hormones, sympathetic and parasympathetic nerves but also has its own natural heart rate.
Atrial contraction
SA node fires, atria start to contract and add pressure to top up missing 20% in the ventricle.
Isovolumetric ventricular contraction (systole)
AV node-> AV bundle -> wall of ventricle -> fast contraction. Super fast phase 0.05 sec. Ventricular pressure exceeds atrial pressure and both valve closes causing the first lub sound. Atrial pressure < ventricular pressure (rising) < arterial pressure.
Isolvolumetric ventricular relaxation
the ventricle relaxes, ventricular pressure drops suddenly and the flow reverses in the aorta therefore the aortic valve closes causing the second heart sound. 0.05 sec phase. Atrial P < vent P (lowering) < arterial P.
ventricular ejection
systole continues, but now ventricular pressure exceeds aortic pressure and aortic valve cusps open quietly. Blood leaves ventricle. Blood is ejected into the aorta faster than it can run off, this pressure in the ventricle and aorta continues to rise steeply but will drop off.