medicines safety Flashcards

1
Q

name 6 points in a hospital where medication errors can occur

A

admission, prescribing, dispensing, administration, monitoring, discharge

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2
Q

why is medicines reconciliation important?

A

ensures accuracy, prevents errors during transitions of care, maintains continuity

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3
Q

what contributes to errors during admission?

A

inaccurate drug history, poor reconciliation, reliance on patient memory

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4
Q

what actions can pharmacy professionals take to prevent these errors?

A

use of dose alerts and clinical decision support systems (CDSS)
medication reconciliation
clear documentation (no “as directed”)
direct communication with prescribers
educating patients
reporting incidents

use of standardised protocols (e.g. MTX only once-weekly).
dose alerts and CDSS (clinical decision support systems).
patient-held records (e.g. RA monitoring booklets).
remove high-risk products (e.g. MTX 10mg tablets where possible).
ensure second checks for high-risk meds (but evidence is limited).
education and training (e.g. opioid stewardship, PPP for valproate).

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5
Q

how does this link with other pharmacy practice teaching?

A

medicines optimisation principles
role of MSOs and NRLS reporting
medicines reconciliation (NICE/NPSA guidance)
shared care agreements
high-risk medicines protocols

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6
Q

what’s the pharmacist’s role in discharge?

A

check TTAs, document med changes, ensure patient & GP are informed

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7
Q

why is it important to involve patients in their medication safety?

A

they can catch discrepancies, understand their meds, and report issues

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8
Q

what is Reason’s Accident Causation Model?

A

“Swiss cheese” model where system failures align and allow an error to pass through every layer of defence

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9
Q

what are the three layers of error in Reason’s model?

A

latent conditions → error-producing conditions → active failures

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10
Q

define active failures in Reason’s model

A

slips & lapses: right plan, poorly executed
rule-based mistakes: wrong rule applied
knowledge-based mistakes: no clear rule, unfamiliar situation

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11
Q

what are active failures?

A

slips, lapses, mistakes, and violations made by front-line staff

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12
Q

give examples of mistakes

A

wrong rule used (rule-based), lack of knowledge (knowledge-based)

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13
Q

what’s the difference between a slip and a lapse?

A

slip = attention error
lapse = memory error

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14
Q

give real-life examples of these failures

A

rule-based: pharmacist assumes weekly med is daily
knowledge-based: unfamiliar side effect misjudged as minor
slip: nurse draws wrong drug due to look-alike packaging

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15
Q

how does Reason’s model explain the methotrexate case?

A

active: wrong dose prescribed.
error-producing: poor med rec, comms failure.
latent: no alert in system, shared care issues

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16
Q

how can Reason’s model help understand medication errors?

A

identifies multiple system weaknesses (e.g. MTX case)
emphasises layers of defence: prescribers, pharmacists, patients
encourages system-wide fixes, not individual blame

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17
Q

how can Reason’s model guide error prevention?

A

helps identify deeper system flaws, not just individual blame

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18
Q

what are the three levels of incident reporting?

A

local (within pharmacy), organisational (e.g. trust), national (e.g. NRLS)

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19
Q

what is the NRLS and what is it for?

A

the National Reporting and Learning System collects incident reports to support system learning and safety improvements

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20
Q

what’s a near miss?

A

an error that could have caused harm but was caught in time

21
Q

why might pharmacists underreport incidents?

A

they view interventions as part of routine, time pressure, lack of feedback

22
Q

what is an MSO and their role?

A

a Medication Safety Officer ensures local incident reporting and learning, feeds into NRLS, and receives alerts via MSOnet

23
Q

what are key principles of quality improvement?

A

systems thinking
continuous learning
root cause analysis
PDSA cycles
stakeholder involvement

24
Q

what does PDSA stand for?

A

plan, do, study, act

25
what is FMEA used for?
predict potential failures before system changes are implemented
26
why is data important in quality improvement?
to measure change and assess if improvement occurs
27
what should you do when an error reaches a patient?
inform the patient/family (duty of candour) stop the drug if needed treat harm caused (e.g. monitoring, transfusions) document and report reflect and improve systems
28
why is communication vital in responding to errors?
prevents repetition ensures accurate handover promotes learning avoids misinterpretation (e.g. MTX post-it note case)
29
what’s the difference between blame culture and just culture?
just culture focuses on learning, not blaming individuals
30
list some approaches to error reduction
standardised processes, tech use, staff training, good communication, involving patients
31
what is SBAR used for?
structured communication during handovers (Situation, Background, Assessment, Recommendation)
32
name strategies to reduce medication errors
electronic alerts removing high-risk options (e.g. MTX 10mg tabs) patient-held records medicines reconciliation avoiding ambiguous prescribing education and clear labelling
33
why is valproate a safety concern?
it’s teratogenic - 14,000 children have been harmed due to in utero exposure
34
what’s the valproate Pregnancy Prevention Programme (Prevent)?
original packaging contraception counselling patient card + guide risk assessment for all patients with uterus, up to age 55 clinical decision support
35
what are risks associated with opioids?
respiratory depression addiction overdose especially problematic in non-cancer chronic pain
36
how can we reduce opioid-related risks?
deprescribing alternative therapies monitoring programs patient agreements care with immediate vs sustained release formulations
37
what are the risks with fluoroquinolones?
tendon rupture nerve damage mental health issues → should be used only when no alternatives available
38
what are Serious Shortage Protocols (SSPs)?
allow pharmacists to substitute products or reduce quantities during drug shortages without returning to prescriber
39
name examples of critical medicines where timing matters
Parkinson’s meds insulin antiepileptics warfarin
40
what are the consequences of omitting Parkinson’s medications?
worsening tremors confusion agitation increased rigidity
41
how is inequity a safety issue?
ethnic, gender, language, and age-related disparities lower socioeconomic status = ↑ PIP interventions: targeted reviews, inclusive communication
42
how is climate change linked to medication safety?
some meds (e.g. inhalers, anaesthetics) have high carbon footprints reducing waste, using low-emission options supports sustainable healthcare
43
name two safety practices with little evidence
separating meds on shelves second person checking
44
why is MTX high-risk?
once weekly dosing, narrow therapeutic index, serious toxicity risk
45
what interventions reduce MTX errors?
one strength supply, system alerts, patient monitoring booklets
46
what went wrong in the apixaban case?
poor discharge communication; patient took both apixaban and dalteparin
47
what was the CHUMS study about?
medication errors in care homes – prescribing, admin, monitoring, dispensing
48
what did the CHUMS study find?
7/10 residents exposed to at least one error; many due to poor communication and systems