Medications

Question 1

Statin induced myopathy and rhabdomyolysis

Answer 1

All but pravastatin are metabolized by Cyp450, incidence will be increased by CYP inhibitors.

Question 2

Foscarnet

Answer 2

Inhibits DNA pol and reverse transcriptase, does not require activation
Can be used for HSV or CMV

Question 3

Trastuzumab

Answer 3

Binds HER2

Cardiotoxic: Reversible myocardial stunning

Question 4

Methimazole

Answer 4

Inhibits thyroid peroxidase, which is responsible for iodine organification and coupling of iodotyrosines

Question 5

PTU

Answer 5

Inhibits thyroid peroxidase, which is responsible for iodine organification and couple of iodotyrosines,

Unlike methimazole, it also decreased conversion of T4 to T3 in the periphery.

Question 6

Doxorubicin

Answer 6

Topoisomerase II inhibitor
Binds iron to create free radicals
Side effect:
Dilated cardiomyopathy

Question 7

Bleomycin

Answer 7

Free radical formation

SE: pulmonary fibrosis

Question 8

Cisplatin

Answer 8

Cross-links DNA
SE:
Nephrotoxic
Ototoxic
Peripheral neuropathy

Question 9

Cyclophosphamide

Answer 9

Cross links DNA

SE
Hemorrhagic cystitis
Bladder cancer

Question 10

Paclitaxel

Answer 10

Inhibits microtubule diassembly
SE
Neuropathy

Question 11

Vincristine/Vinblastine

Answer 11

Binds beta tubulin to inhibit microtubule formation
SE
Neuropathy

Question 12

Competitive vs Noncompetitive charts

Answer 12

Competitive inhibition = Vmax unchanged, but requires higher dose
Noncompetitive = Vmax changes, E50 unchanged

Question 13

Bisphosphonates

Answer 13

inhibit osteoclast reabsorption of bone

Question 14

Denosumab

Answer 14

Prevents RANK L from binding RANK

Reduces differentiation and survival of osteoclasts

Question 15

Primaquine

Answer 15

Kills hypnozoites

Question 16

Nondihydropyridine CCB side effects

Answer 16

constipation, bradycardia, AV block, worsening HF in patients with HFrEF

Question 17

Dont use this NM blocking agent with myasthenia gravis

Answer 17

Vecuronium

Question 18

High ateriovenous gradient in an inhaled anesthetic

Answer 18

lots of loss of the anesthetic in peripheral tissues, slow onset of action, takes longer to accumulate in blood and brain.

Question 19

Warfarin induced skin necrosis

Answer 19

Sharply demarcated purpuric lesion
Protein C or S deficiency
Several clotting factors are Vitamin K deficient but with naturally lower levels of C or S patients experience a temporary hypercoaguable state until other factors are appropriately inhibited.

Question 20

Zolpidem MoA

Answer 20

GABAa agonist

primarily hypnotic effects

Question 21

Etaneracept

Answer 21

decoy TNFa recptor attacked to Fc portion of an antibody