Med Sci check in Flashcards
Eukaryote pathogens
-Protists
-Helminth/ectoparasites
-Fungi
Microorganism pathogen
-Bacteria
-Fungus
-Protists
-Helminths
Pathogens
-Virus
-Prions
-Helminths
-Bacteria
-Fungi
-Protists
John Snow
Epidemiology
Louis Pasteur
Germ Theory
Robert Koche
Bacteriology/causal agents of disease
Ignaz Semmelweis
Aseptic technique
Virus reproduction
Lysogenic cycle
Bacteria reproduction
Binary Fission
Prion reproduction
Misfolded protein going near other tissues
Protist Reproduction
Mitosis
Helminth Reproduction
Meiosis
Fungi reproduction
Mitosis/Meiosis
Miasma
1840- poison vapors are what make us sick
Pathogen
Biological mechanism of disease progress
Koch’s postulates
- Microorganism must be found in affected organisms but not healthy ones
2.Microorganism must be isolated from diseased organism and grown in pure culture
3.Cultured organism must cause disease when introduced to healthy organism
4.Microorganism must be reisolated from inoculated. diseased host must be identical as causative agent
Problems w/ Koch’s postulates
-Does not work for virus/prions
-Some people carry pathogens but show no symptoms
-Some pathogens can’t be grown in pitri dish
-Not all capable of contracting disease
-Mutations occur, pathogens will not look exact same
Chain of infection
Pathogen
Reservoir
Portal of exit
Means of transmission
Portal of entry
New host
Antiseptic
For people
Disinfectant
NOT FOR PEOPLE !!
Virus
-20-200nm
-Capsid (Made of protein), nucleic acid (DNA, RNA)
-May have envelope
eg. COVID-19, Influenza
Bacteria
-Single cell chromosome, ribosome, cytosol
-1-10 micrometers
-Groups = aggregations
-Some produce harmful toxins
-Glucose = peptidoglycan
eg. e.coli, salmonella typhi, etc
Gram stain
Determines how will an antibiotic will work
Shapes of bacteria
Coccus (Circular)
Bacilli (Oval)
Spirilla (Cork screw
Bacteria grouping
Diplo - 2
Staphylo - cluster
Strepto - chain
Protists
-Nucleus, membrane bound organelles
-10-100 micrometers
-Live in water
eg. Malaria, Giardiasis
Fungi
-5-15 micrometers
-Some do not cause human disease
-Some produce toxins
-Cell division = budding
-Like moist areas
-Multi. cell. branch out = hyphae
eg. Athlete’s foot, ringworm
Helminth/Ectoparasites
20-80 micrometers as egg
-1 meter as adult
-poor sanitation, moist/warm areas
-Undercooked meat
-Tapeworm, roundworms, flukes
ectoparasites - lice/scabies, 150-400 micrometers
Prions
Protein
Holes in brain
*Proteinaceous infectious particle
15nm
RARE
Which bacteria has pep.
Gram +
The plague
Yersinia Pestis
Bacteria
Vector —- FLEAS !!
Lysogenic cycle
PROVIRUSES !!
-Eventually goes to lytic
-Can take years
-Integrates its DNA into host cell
Lytic Cycle
DESTROYS CELLS !!
-Hours to days
Principles of surgical Asepsis
-Sterile object only remains sterile when touching another sterile object
-Only sterile objects can be on sterile field
-Anything that is sterile that is out of range or view is contaminated
-If sterile object exposed to air for 15-20 minutes, may be contaminated
-If sterile field comes into contact w/ moisture, moist area is contaminated
-Liquid flows in direction of gravity; forceps point down
-1 inch around sterile field = contaminated
PPE
Personal protective equipment
eg. gloves, goggles, etc.
Danger zone for bacteria replication
4 degrees c-60 degrees c
Principles of food safety
-Chill
-Cook
-Separate
-Clean
Infection timeline
-Infection (Exposure)
-Latent period
-Incubation period
-Period of communicability
Virulence
Quantitative term (How sick you get; how well a pathogen bypasses host’s defenses)
Pathogenicity
Qualitative, causes disease or nah
Types of reservoir
Human
Animal
Environment
Zoonosis
Disease spread from animal with vertebrae to human
Portals of exit
-Respiratory
-Digestive
-Skin
-Genitourinary
-Blood
-Breastmilk
Passive carrier
Does not reside in person
Active carrier
Resides in person
Portals of entry
-Skin
-Mucous membranes
-Blood
-Placeta (Mother to child)
-Digestive
CHOLERAAAAAAAAAAAAA
Vibrio cholerae
-Bacteria
Direct contact
-Vertical
-Horizontal
-Droplets
Types of direct contact
Direct contact *Horizontal, vertical, droplets
Injection/Inoculation
Contact with soil
MALARIAAAAAAAAAAA
Plasmodium falciparum
-Protozoan
Droplet
-1m or less
-Larger than 5 micrometers
-Lasts for minutes
-Direct
-EBOLA
Airborne
-Over 1m
-Smaller than 5 micrometers
-Lasts for hours
-Indirect
-Measles
Drug resistant pathogen (Superbugs)
Pathogens that grew up to be a bitch and resist medicine
-eg. Candida auris, Staphlyococcus auris, TUBERCULOSIS ??
Nosocomial infection
Pathogen picked up from hospital
Secondary infection
A new pathogenic infection when you already have one
-First will wear down immune system, allowing other to get in
-eg. pneumonia
Opportunistic pathogen
A pathogen that can only enter given the opportunity (Eg. weakened immune system)
Cryptosporidiosis
Crypto parvum
-Vehicle (Water)
Anthrax
Bacillus anthracis