Med School Mock Flashcards

1
Q

familial adenomatous polyposis inheritance pattern

A

autosomal dominant

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2
Q

what mechanism stops bleeding after venepuncture

A

platelet and fibrin plug forming over the area of damaged endothelial wall

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3
Q

malignan neoplasm growing with an area of metaplasia

A

squamous cell carcinoma

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4
Q

what is a sarcoma

A

cancer (malignant) that starts in tissues like bone or muscle

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5
Q

first line management for hyperkalaemia

A
  • calcium chloride or calcium gluconate
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6
Q

Which artery plays an important role in erectile function

A

Internal pudendal artery

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7
Q

give post renal causes of AKI

A

mechanical obstruction of urinary outflow tract

- BPH, stones

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8
Q

give intrinsic causes of AKI

A
  • acute tubular necorsis
  • glomerulonephritis
  • interstitial nephritis
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9
Q

give pre renal causes of AKI

A

decreased renal perfusion

  • hypovolaemia
  • haemorrhage
  • sepsis
  • over diureses
  • HF
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10
Q

what triggers release of aldosterone

A
  • decreased blood pressure is detected => adrenal gland is stimulated by stretch receptors => aldosterone release
  • RAAS: angiotensin II acts on adrenal cortex => aldosterone release
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11
Q

first line imaging for suspected stroke

A

CT !

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12
Q

Wilsons disease presentation

A
  • tremor
  • sloppy of small handwriting
  • dysarthria
  • kayser-fleischer ring
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13
Q

myasthenia graves presentation

A
  • muscle fatiguability
  • drooping eyelids
  • double vision
  • slurred speach
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14
Q

what is myasthenia gravis

A
  • autoimmune condition that affects ACh uptake

- circulating antibodies against AChR impair neuromuscular transmission

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15
Q

parkinsons presentation

A

triad:

  • resting tremor (pill rolling)
  • rigidity (cogwheel)
  • bradykinesia (small handwriting, shuffling gait, reduced facial movements + expressions)
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16
Q

huntingtons investigation

A

CAG repeat testing

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17
Q

huntingtons presentation

A
  • chorea
  • loss of coordination
  • irritability and impulsivity
  • personality change
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18
Q

management for Gillian barre syndrome

A
  • alert ITU
  • Start intravenous immunoglobulin
  • Start plasma exchange (IgA deficient or renal failure)
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19
Q

aortic stenosis on clinical exam, feature

A

small volume and slow rising pulse

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20
Q

aortic regurgitation on clinical exam, feature

A
  • collapsing pulse

bounding and forceful, rapidly increasing and subsequently collapsing

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21
Q

commonest cause of myocardial dysfunction that leads to heart failure

A

ischaemic heart disease

22
Q

describe venous ulcers

A
  • caused by venous insufficiency
  • appear shallow with irregular borders and a granulating base
  • often located over the medial malleolus
  • most common type of leg ulcer
  • prone to infection
23
Q

describe arterial ulcers

A
  • caused by a reduction in arterial blood flow => decreased perfusion of the tissues => poor healing
  • small deep lesions with well-defined borders and a necrotic base
  • commonly occur distally at sites of trauma and in pressure areas (e.g the heel)
24
Q

extra intestinal manifestation of crohns

A

Erythema nodosum

25
what type of jaundice does pancreatic cancer cause
post hepatic | bile duct becomes blocked by the tumour
26
potassium levels in DKA
hyperkalaemia is common but hypokalaemia is an indicator of severe DKA
27
cause of primary amenorrhoea
turners syndrome
28
aldosterone effect on electrolytes
mineralocorticoe steroid hormone that acts on kidneys to: - increase sodium reabsorption in distal tubule - increase potassium secretion in distal tubule - increase H+ secretion in collecting ducts
29
cause of secondary hyperaldosteronism
renal artery stenosis
30
what does high ACTH cause (electrolytes(
decreasing the excretion of sodium and increasing that of potassium in the urine blood: - low potassium - high Na
31
symptoms of hypoglycaemia
- Palpitations - Poor concentration - Shaking - Sweating
32
what do you do if patient is hospitalised due to the adverse drug reaction (ADR).
Report the ADR via the yellow card system
33
ITP vs TTP symtoms
ITP: not enough platelets => blood to leak from small blood vessels - bruising, Petechiae, bleeding, blood blisters in mouth TTP: small clots prevent orange working - headaches, vision changes, kidney failure - also signs similar to ITP
34
what immune cells important in COPD
neutrophils
35
what immune cells important in asthma
mast cells and eosinophils
36
most common form of lung cancer
adenocarcinoma
37
what does innate immune system respond to
It responds in the same way to all germs and foreign substances, which is why it is sometimes referred to as the "nonspecific" immune system
38
describe compliment levels in SLE
low
39
what cancer associated with sjogens
NHL
40
how does Vibrio cholerae cause diarrhoea
A toxin that deregulates ion transport in epithelial cells
41
how do penicillins work
work by disrupting peptidoglycan => damages cell wall
42
what is meningococcal meningitis caused by
Neisseria meningitidis
43
reason for breast lumps
- cancer - ductal papilloma - cyst - breast implant ruptured
44
what dementia is Parkinson's associated with
Lewy body dementia
45
what would you seen on CT in Parkinson's
nothing/ no pathology
46
what can trigger a migraine
cheese, caffeine, stress
47
alzeihmers risk factors
- downs syndrome | - depression
48
hallmark features of Alzheimer's - histology
- Extracellular deposition of beta amyloid plaques - Tau -neurofibrillary tangles - Damaged synapses - Cortical atrophy (hippocampus)
49
causes of Gillian barre
- EBV | - CMV
50
Gillian barre treatment
- IV immunoglobulins | - plasma exchange
51
a transient loss of vision in one or both eyes
- Amaurosis fugax