Mechanobiology II Flashcards
1
Q
What are 3 mechanosensors?
A
- Piezo ion channels
- Integrins
- Caveolae
2
Q
What are Piezo ion channels?
A
Ion channels that open under mechanical stress / stretch.
Activated by membrane / cortical tension.
3
Q
What are mutated piezo ion channels linked with?
A
Cancer
4
Q
What are Integrins?
A
Mechanosensors that link the inside of the cell with the ECM.
Inside-out signalling
5
Q
What can be communicated through integrins?
A
Stiffness
6
Q
What does talin do?
A
Binds to integrins to relay signals. Cell~>ECM
7
Q
What is a Caveolae?
A
An invagination on plasma membranes that is responsive to stretch.
Helps cell withstand mechanical stress.
