Mechanisms Of Platelet Plug (Primary Homeostasis)

Question 1

1. ________ come in contact with a damaged vascular surface, especially with ________ fibers

Answer 1

Platelets; collagen

Question 2

2. Platelets change in shape and ______; they assume irregular forms with pseudopods
   protruding from their surfaces.

Answer 2

Swell

Question 3

3. Their contractile proteins contract forcefully and cause the release of _____ that contain multiple active factors; they become ______ so that they adhere to collagen in the tissues and to a glycoprotein called ________ (leaks into the traumatized tissue from the plasma) via GPIb. This is called ________

Answer 3

Granules; sticky; von Willebrand factor; adhesion

Question 4

4. The platelets then secrete increased quantities of ADP and________, and their enzymes form ________ A2

Answer 4

platelet-activating factor (PAF); thromboxane

Question 5

5. The _______ and thromboxane in turn act on nearby platelets to activate them as well,

___________ is a cytokine secreted by neutrophils, monocytes, and platelet cell membrane lipids

Answer 5

ADP; Platelet-activating factor (PAF)

Question 6

6. Once activated, platelets express the ________ receptor which can then bind with vWF or ________

Fibrinogen facilitates the formation of crosslinks between platelets, aiding platelet aggregation to form a platelet plug called ______

Answer 6

GPIIb/IIIa; fibrinogen; aggregation

Question 7

7. Simultaneously, platelets are also
   activated to release a number of
   chemicals (release _____ or
   _____) that further facilitate vasoconstriction, adhesion, and
   aggregation forming platelet plug

Answer 7

Reaction, secretion