Fibrinolysis

Question 1

Lysis of blood clot inside the blood vessel is called _______.
It helps to remove the clot from _______ of the blood vessel.

This process requires a substance called ______ or fibrinolysin.

Answer 1

fibrinolysis; lumen
plasmin

Question 2

Formation of Plasmin

1.Plasmin is formed from inactivated glycoprotein called _______.

2. Plasminogen synthesized in _______.
3. Plasminogen trapped in the clot is converted into plasmin by ___________(t-PA) lysosomal enzymes and thrombin.

Answer 2

plasminogen;
Liver
tissue plasminogen activator

Question 3

4. The t-PA and lysosomal enzymes are released from damaged ________ and
   damaged ________.
5. The t-PA is always inhibited by a substance called _________.
6. It is also inhibited by factors V and VIII.
7. Besides t-PA, there is another plasminogen activator called ________ (u-PA).

Answer 3

endothelium; tissues
t-PA inhibitor
urokinase plasminogen activator

Question 4

Activation of Plasminogen

1. During intravascular clotting, the endothelium of the blood vessel secretes ________.
2. Thrombomodulin combines with thrombin and forms __________-_______ complex
3. Thrombomodulin-thrombin complex activates

Answer 4

thrombomodulin
thrombomodulin-thrombin
protein C

Question 5

4. Activated protein C inactivates factor V and VIII in the presence of a cofactor called _________.
5. Protein C also inactivates the t-PA inhibitor, activate _______
6. Activated t-PA and lysosomal enzymes activate ________ to form _______.
7. Plasmin digest fibrin fibers, fibrinogen, Factor V, Factor VIII, prothrombin, and Factor XII. In turn removes unnecessary _______

Answer 5

Protein S
t-PA
plasminogen; plasmin
blood clot.