Extrinsic Pathway

Question 1

Step 1 (____________)

Key to the clotting mechanism is
the release of factor _____ tissue
_________ (TPL) from the
injured tissue.

Answer 1

Release of TPL;
III; thromboplastin

Question 2

Step 1 continuation

TPL is the tissue factor composed of _________ from the membranes
of the tissue plus _______
complex that functions as a proteolytic enzyme.

Answer 2

phospholipids; lipoprotein

Question 3

Extrinsic (________) pathway for initiating clotting

Answer 3

Tissue factor

Question 4

Step 2 (________)

TPL converts factor _____ to its
active form (_____).
This is the key step in _______ mechanism.

Answer 4

Activation of VII;
VII (7); VIIa (7a)
extrinsic

Question 5

Step 2 continuation

VIIa directly activates not
only ______ (_________ factor), but also _______ (_______ factor) part of
intrinsic pathway.
Thus, it also influences ______ mechanism of activation of factor X.

Answer 5

X, Stuart-Prower;
IX, Christmas;
intrinsic

Question 6

Step 3 (_________)

VIIa converts X to ______.
This process is accelerated in the
presence of _______ , ______ phospolipid and ________.

Answer 6

Activation of X; Xa (10a);
calcium; platelet; TPL