Intrinsic Pathway

Question 1

Intrinsic (_________) Pathway
Begins with trauma to the ______ or exposure of the blood to ______ from the vessel wall

Answer 1

Contact Activation; blood; collagen

Question 2

Step 1 (________)

Starts with contact of ______ factor (____) with a _______ charged surface or exposed collagen of the
injured vessel wall.

Answer 2

Activation of XII;
Hageman, XII;
negatively (-)

Question 3

Formation of primary complex on collagen by ______________ (HMWK), _________, and XII (Hageman factor)

Answer 3

high molecular-weight kininogen; prekallikrein

Question 4

Prekallikrein is converted to ________ and XII becomes
________.

Answer 4

kallikrein; XIIa

Question 5

Exposed collagen stimulates
platelet ______ and ________ before initiating blood coagulation

Answer 5

adhesion; aggregation

Question 6

Step 2 (_______)

Activated XII (XIIa) converts
_______ to its active form (____).

This reaction also requires
high molecular-weight kininogen(HMWK) and is accelerated by _______.

Answer 6

Activation of XI;
XI, XIa
Prekallikrein

Question 7

Step 3 (__________)

______ then converts IX to IXa,
which is accentuated by ______
which is part of ________ pathway
________ accelerates this process.

Answer 7

Activation of IX;
XIa; VIIa
extrinsic
Calcium

Question 8

Step 4 (__________)

Final step in activation of
_________ activator is
activation of X.

________ causes activation of X to
Xa.

Answer 8

Activation of X;
prothrombin, IXa;

Question 9

Step 4 continuation

The membrane phospolipid
calcium and activated factor
VIII act as ________ for the
activation of _________
factor

Formation of _______ is the key
to the process of activation
of X.

Answer 9

cofactors; Stuart-Prower
VIIIa