Formation Of Fibrin From Fibrinogen

Question 1

Stage 3: Formation of Fibrin from Fibrinogen

The final stage of blood coagulation in which thrombin acts as an _______ to convert fibrinogen (Factor ____) to fibrin

First, the fibrin monomers are formed and afterward, they are polymerized to _______ (blood clot).

Has 3 steps

Answer 1

enzyme; I (1)
fibrin thread

Question 2

1. Proteolysis of soluble fibrinogen

Removal of ___ _____ peptides from each molecule of fibrinogen forming 1 fibrin monomer.

Answer 2

4; LMW

Question 3

2. Polymerization of fibrin monomers

Fibrin monomers automatically polymerize with other fibrin monomer molecules to form _____ fibers

This happens within seconds to form long fibrin fibers that constitute the _______ of the blood clot

Answer 3

fibrin;
reticulum

Question 4

3. Stabilization of fibrin polymer

Thrombin activates ______ (XIIIa) from plasma and platelets.

This cause _____ bonds between fibrin monomers as well as multiple
cross-linkages between adjacent fibrin fibers.

Answer 4

fibrin-stabilizing factor;
covalent