Homeostasis

Question 1

The process of arrest of bleeding while maintaining blood in a fluid state within the vascular system.

Answer 1

Homeostasis

Question 2

Homeostasis is mechanism by which loss of blood from vascular system is prevented by a complex interaction of ________, ________ and _________

Answer 2

Vessel wall, platelets and plasma proteins

Question 3

2 stages of Homeostasis

1. ________ : This is the _____ stage during which the vascular wall and platelet interact to limit the blood loss from the damaged vessel.
   Also called temporary hemostasis
2. _________: A stable ______ clot is formed from clotting factorsby enzymatic reactions.
   Also called definitive hemostasis as the formation of clot in the vicinity
   of platelet plug finally stops bleeding

Answer 3

Primary; initial
Secondary; fibrin clot

Question 4

Steps of hemoestasis

1. _______
2. Temporary ___________ ___ formation
3. Blood _______

Answer 4

Vasoconstriction;
Hemostatic plug
Coagulation

Question 5

Is the ________ response of blood vessel to injury.

Occurs due to the ______ of vascular smooth muscle in response to injury.

It instantaneously _______ loss of blood and also helps in __________ formation

Answer 5

Vasoconstriction; immediate; contraction; decrease; platelet plug

Question 6

Contraction of vascular smooth muscle to injury is initially ________ response (________-induced contraction)

Answer 6

Mechanical; stretch

Question 7

Vasoconstriction is maintained and potentiated by secretion of
__________ substances from the activated ________.

Answer 7

Vasoconstrictor; platelets

Question 8

The 2nd step of hemostasis is the formation of ________

This occurs due to three properties of platelets:
adhesion,
aggregation,
and release ______ (secretion).

Answer 8

Platelet plug; reaction

Question 9

are minute
discs formed in the bone marrow from _________

Answer 9

Platelets (thrombocytes); megakaryotes

Question 10

_______-granules contain proteins of ______ molecular weight, including von Willebrand Factor (vWF), factor V and fibrinogen.

________ - granules contain ______ molecular weight molecules such as ATP, ADP, serotonin, and calcium ions.

Answer 10

Alpha; high
Dense; low

Question 11

Platelet Cell Membrane
_______ that repulses adherence to normal endothelium and yet causes adherence to injured areas of the vessel wall, especially to injured endothelial cells and even more so to any exposed collagen

_________ activate multiple stages in the blood-clotting process

Answer 11

Glycoprotein coat (GP)
Phospholipids

Question 12

How many days is the half life of platelets

Answer 12

8-12 days