Mechanisms Of Heart Failure Flashcards
Define heart failure
Heart’s inability to meet metabolic needs of the peripheral tissues, or instances when the heart can only do so in the presence of increased filling pressures
Forward failure means
Poor cardiac output
Characteristics of forward failure
(4)
Weakness
Exercise intolerance
Hypothermia
Decreased tissue perfusion
What does backward failure mean?
Congestion
Characteristics of backward failure
Increased venous filling pressure
Pulmonary edema/pleural effusion
Ascites
What are the Neurohormonal pathways involved in heart failure?
Renin-angiotensin-aldosterone system
Sympathetic nervous system
Natriuretic peptides
Endothelin/vasopressin systems
Draw the RAAS system
See image below
What is the Primary trigger for activation of the RAAS system?
Heart’s inability to provide normal renal perfusion
Decreased renal blood flow and NaCl delivery to the distal nephron induces renin release from the macular densa in the kidney.
What happens next?
Renin converts angiotensinogen (from liver) to angiotensin 1
Angiotensin I is converted to angiotensin II via
ACE in pulmonary vasculature
What are the functions of angiotensin II?
Renal Na/H2O retention
Production of aldosterone
Myocardial apoptosis
Cardiac/vascular remodeling/fibrosis
Increase thirst
ADH release
Vasoconstriction
What are the main effectors of the SNS (sympathetic nervous system)?
(2)
Epinephrine
Norepinephrine
What are the main results of
What are the main results of SNS activation?
Increased HR
Increased CO
Increased blood flow
What is the SNS short term response?
Chronic activation
Adrenergic receptor downregulation
Persistent tachycardia
Increased myocardial o2 demand
Myocyte necrosis
**further cardiac damage