MDS/MPD Flashcards

1
Q

CML Genetic Translocation

A

Abelson tyrosine kinase / BCR translocation

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2
Q

AML-M3 genetic translocation

A

PML/RAR fusion protein. Retinoic acid causes differentiation of neutrophil

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3
Q

ALL genetic translocation

A

BCR/ABL translocation

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4
Q

Burkitt Lymphoma Translocation

A

Myc is transloated and under control of IGH. MYC is a powerful proto oncogene, bHLH transcription factor which recruits HATs

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5
Q

Tcell Lymphoma translocation

A

MYC protooncogene is under Tcell Receptor Promoter

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6
Q

PV genetic mutation

A

JAK is mutated, increasing kinase activity. Downstream of many cytokine receptors

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7
Q

Li fraumeini disease

A

due to p53 tumor supressor mutation, prone to leukemia

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8
Q

Fanconi Anemia

A

Defective DNA repair, leads to AML.

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9
Q

ALL

A

Common in children, TdT and PAS positive, small to medium lymphoblasts, neutropenia, thrombocytopenia, anemia, lymphblasts and pro lymphocytes

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10
Q

aml

A

common in adults, Sudan Black and MPO positive, medium to large myeloblasts, anemia, neutropenia, thrombocytopenia

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