MDS/MPD Flashcards
CML Genetic Translocation
Abelson tyrosine kinase / BCR translocation
AML-M3 genetic translocation
PML/RAR fusion protein. Retinoic acid causes differentiation of neutrophil
ALL genetic translocation
BCR/ABL translocation
Burkitt Lymphoma Translocation
Myc is transloated and under control of IGH. MYC is a powerful proto oncogene, bHLH transcription factor which recruits HATs
Tcell Lymphoma translocation
MYC protooncogene is under Tcell Receptor Promoter
PV genetic mutation
JAK is mutated, increasing kinase activity. Downstream of many cytokine receptors
Li fraumeini disease
due to p53 tumor supressor mutation, prone to leukemia
Fanconi Anemia
Defective DNA repair, leads to AML.
ALL
Common in children, TdT and PAS positive, small to medium lymphoblasts, neutropenia, thrombocytopenia, anemia, lymphblasts and pro lymphocytes
aml
common in adults, Sudan Black and MPO positive, medium to large myeloblasts, anemia, neutropenia, thrombocytopenia