Mazzariol - CeMV Associated Microscopic Pathology Flashcards
What does CeMV stand for?
Cetacean Morbillivirus
What percentage of CeMV cases exhibit bronchiolo-interstitial pneumonia?
72%
What is pulmonary syncytia, and how common is it in CeMV cases?
Pulmonary syncytia refers to the formation of multinucleated cells in the lungs due to cell fusion, occurring in 65% of cases.
What percentage of CeMV cases show meningoencephalitis, and what does it involve?
69%. It involves inflammation of the brain (encephalitis) and/or the meninges (meningitis).
What are syncytia, and where are they commonly found in CeMV infections?
Syncytia are multinucleated cells formed by the fusion of infected cells. They are found in the lungs, brain (22%), and lymph nodes (19-31%) in CeMV cases.
What is lymphoid depletion, and which organs does it affect in CeMV cases?
Lymphoid depletion is the reduction of immune cells, commonly observed in the spleen and lymph nodes during CeMV infections.
What are viral inclusions in CeMV-infected cells?
Viral inclusions are microscopic changes visible in infected cells, indicating the presence of the virus.
What are the respiratory system effects of CeMV?
Bronchiolo-interstitial pneumonia and pulmonary syncytia.
What are the neurological effects of CeMV?
Meningoencephalitis (69%) and syncytia in the brain (22%).
How does CeMV affect the immune system?
It causes lymphoid depletion in the spleen and lymph nodes, as well as syncytia in lymph nodes (19-31%).
What is the role of syncytia in the pathology of CeMV?
Syncytia indicate viral-induced cell fusion and are found in multiple organs, such as the lungs, brain, and lymph nodes, highlighting systemic infection.
How does CeMV impair cell function?
By forming syncytia, causing lymphoid depletion, and producing viral inclusions in infected cells, CeMV disrupts normal cellular and immune functions.
What tissues/organs should be examined microscopically to confirm CeMV infection?
Lungs, brain, lymph nodes, spleen, and infected cells for viral inclusions.
