MARKERS Flashcards
BRC-ABL
Oncogene: CML, ALL, tyrosine kinase
bcl-2
Oncogene: Follicular and undifferentiated lymphomas; anti-apoptotic moleculre
BRAF
Oncogene, melanoma, Serone/threonin kinase
c-kit
Gastrointestinal stromal tumor, oncogene, Cytokine receptor
c-myc
Burkitt lymphoma, transcription factor
HER2/neu
breast, ovarian, gastric carcinoma with tyrosine kinase
L-myc
Lung tumor; transcription factor
N-myc
Neuroblastoma: transcription factor
ras
colon cancer, lung cancer, pancreatic
GTPase
ret
MEN 2A and 2B; Tryosine kinase
APC
BRCA1
BRACA2
APC = colorectal
BRCA1 = breast and ovarian
BRCA2- breast and ovarian
CPD4/SMAD4
Pancreatic cancer makes DPC or Deleated in Pancreatic Cancer
DCC
Colon cancer: Deleated in Colon Cancer
p16
Melanoma; cyclcin dependent kinase inhibitor 2A
PTEn
breast cancer, prostate cancer, endometrial
Rb
retinoblastoma and Osteosarcoma: inhibits EF2 to stop G1–> S