GI Pathology and Facts

Question 1

An 18 you underwent surgery conducted under general anesthesia. Insignificant past medical hx. Four days later has fever, confucsion and nausea. Labs show elevated AST, ALT and bilirubin. What will you see on liver biopsy? What is the cause?

Answer 1

See massive hepatic necrosis; caused by complication of Halothane exposure; see formation of autoantiBs against liver proteins.

Question 2

Intrahepatic cholestatis is a hallmark of biliary duct obstruction and see in what diseases and from what meds?

Answer 2

Primary Sclerosing Cholangitis and Primary Biliary Cirrhosis; drug induced form oral contraceptives, anabolic steroids and Chlorpromazine

Question 3

Little girls comes in to office with bloody stool and had a +99mmTc-pertechnetate scan in the right lower abdominal quad. What is this significant for? What development process failed?

Answer 3

99mmTc is for ectopic gastric epithelium in the intestines. Girl has Meckel diverticulum which is failure of obliteration of the omphalomesenteric duct. See currant jelly stool, colicky pain and predisposes to intussuscpetion.

Question 4

Failure of ventral and dorsal pancreatic buds to fail leads to

Answer 4

pancreas divisum; often found incidentally

Question 5

Hind gut is part of primitive gut and gives rise to distal 1/3 of transverse colon, descending and sigmoid colon, rectum and upper part of anal canal. Failure of proper descent causes

Answer 5

anal agenesis or imperforate anus