March 17 test 3

Question 1

What is the first line therapy for BPH and what is its MOA?

Answer 1

Finasteride–5a-reductase inhibitor–decreases the conversion of testosterone to DHT

Question 2

Methotrexate can cause myelosuppression which can be reverse with administration of what?

Answer 2

Leucovorin–Folinic acid a folic acid analog

Question 3

What thionamide is used for hyperthyroidism in pregnancy and blocks peripheral conversion of T4 to T3?

Answer 3

Propylthiouracil–PTU

Question 4

What is anti-histone antibody sensitive for?

Answer 4

Drug induce lupus –hydralazine and procainamide

Question 5

What is 1st line therapy for ulcerative colitis?

Answer 5

Sulfasalazine–A combination of sulfapyridine (Antibacterial) and 5-amniosalicylic acid (anti-inflammatory)

Question 6

What antibiotic can cause Cholestatic hepatitis causing jaundice?

Answer 6

Macrolides–especially erythromycin

Question 7

What anti epileptic drug can cause hepatotoxicity, weight gain and is contraindicated in pregnancy because it can cause neural tube defects?

Answer 7

Valproic acid

Question 8

What chemo agent is contraindicated with renal insufficiency due to its nephrotoxicity effect?

Answer 8

Cisplatin/Carboplatin –also have ototoxicity effect

Question 9

What 2 drugs at on the kidney to inhibit uric acid reabsorption in PCT?

Answer 9

Probenecid and sulfinpyrazone

Question 10

What is the most effective way to lower LDL cholesterol in a pt with multiple risk factors for CAD?

Answer 10

Statin and bile acid sequestering combination

Question 11

What condition is characterized by rigidity, myoglobinuria autonomic instability, hyperpyrexia and is caused by antipsychotics. What is the tx for it?

Answer 11

Neuroleptic malignant syndrome (NMS)

Tx: Dantrolene or D2 agonist–bromocriptine

Question 12

What is the MOA of Ondansetron?

Answer 12

5-HT3 antagonist–decreases vagal stimulation

Question 13

What is Lithium used for and what are the major side effects?

Answer 13

Bipolar disorder

Side effects:
LMNOP
-Lithium
-Movement
-Nephrogenic DI
-HypOthyroid
-Pregnancy problems--Ebseins anomaly--malformed tricuspid valve

Question 14

How is ‘redman’ syndrome avoided with vancomycin administration?

Answer 14

Slow infusion over 1-2 hours and pre-treatment with antihistamine