March 17 test 2

Question 1

What are the MAOi’s that can cause hypertensive crisis with ingestion of tyramine products?

Answer 1

Tranylcypromine
Phenelzine
Isocarboxazid
Selegiline

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Question 2

What drug is used for Primary adrenal insufficiency–addison disease because it has mineralocorticoid activity?

Answer 2

Fludrocortisone

Question 3

What is the largest affect seen with the Fibrates?

Answer 3

Major decrease in TGs

Question 4

What is the mechanism of action of the TCAs?

Answer 4

Block reuptake of NE and 5-HT

Question 5

What antireflux drug class is associated with markedly elevated gastrin serum levels and risk of atrophic gastritis?

Answer 5

PPIs

Question 6

What is the mechanism of action of amantadine?

Answer 6

M2 protein inhibitor that prevents viral uncoating

–used for prophylaxis of the flu A

Question 7

What is the MOA of Cromolyn sodium and what is it used for?

Answer 7

Prevents mast cell degranulation and is used for asthma prophylaxis

Question 8

Recombinant IL-2–Aldesleukin is used for what?

Answer 8

Renal cell carcinoma

Question 9

What oral hypoglycemic drugs are associated with a disulfiram-like effect when taken with ETOH?

Answer 9

First generation Sulfonylureas–Chlorpropamide and tolbutamide

Question 10

What is the mechanism of action of Bleomycin?

Answer 10

Induces free radical formation–breaks in DNA strands

Question 11

What protease inhibitor used for HIV can cause nephrotoxicity and hematuria?

Answer 11

Indinavir

Question 12

What is the MOA of Doxorubicin and Daunorubicin?

Answer 12

Generate free radials and intercalate in DNA–breaks in DNA

Question 13

Why should pts

Answer 13

Risk of toxic megacolon

Question 14

What drug is used for benzodiazepine toxicity and what is the mechanism of action?

Answer 14

Toxicity is most likely going to show very low RR–give flumazenil which is a competitive antagonist at GABA bento receptor