March 17 test 1

Question 1

Pt presents with bleeding gums after brushing her teeth and she is getting her wisdom teeth pulled and she is worried about excessive bleeding. What disorder does this pt have and what is used to treat it?

Answer 1

von Willebrand disease–use desmopressin to increase vWF release from the stored endothelium

Question 2

What bacteria is responsible for causing subacute bacterial endocarditis?

Answer 2

Viridans streptococci–S. sanguinis

FROM JANE

• Fever
• Roth spots-white spots on retina surrounded by hemorrhage
• Osler nodes-raised lesions on finger or toe pads
• Murmur
• Janeway lesions-red lesions on palm or sole
• Anemia
• Nail-bed hemorrhage
• Emboli

Question 3

What anti arrhythmic is associated with pulmonary fibrosis, hepatotoxicity, hypo/hyperthyroid, photo dermatitis and cardiovascular effects?

Answer 3

Amiodarone

Question 4

What are the 3 common drugs that are eliminated via zero order elimination?

Answer 4

Phenytoin
Ethanol
Aspirin

PEA–a pea is round like 0

Question 5

What is the tx for Echinococcus granulosus and what is not recommended for tx?

Answer 5

Albendazole

Surgical removal not recommended because released cysts can cause anaphylaxis

Question 6

Pts with CF are at an increased risk of ________ caused by pseudomonas aeruginosa infection.

Answer 6

Bronchiectasis–due to obstruction and dilation of the bronchi

Question 7

Child on testosterone or methyl testosterone is at an increase risk of what?

Answer 7

Premature closet of epiphyseal plates–due to Ca++ deposition

Also causes:

• Increased LDL
• Decreased HDL
• Gonadal atrophy–due to inhibition of LH release

Question 8

What does Abciximab bind in order to inhibit activation of fibrinogen which facilitates platelet aggregation?

Answer 8

Glycoprotein receptor IIb/IIIa

Question 9

What med used for bipolar disorder (mood stabilizer) can cause nephrogenic DI?

Answer 9

Lithium

Question 10

What congenital cardiac abnormality is associated with Lithium?

Answer 10

Ebstein anomaly–apical displacement of tricuspid valve downward into RV, artiralization of the right ventricle, enlargement of the RA and right sided HF.

Question 11

What is the MOA of the drug used for the tx of status epilepticus?

Answer 11

Benzodiazepines–increase FREQUENCY of Cl- channel opening through GABAa action

Question 12

What diuretic causes decreased Ca++ excretion in the urine and has a risk of hyperglycemia?

Answer 12

-Thiazides