Malignancy: Neutropenia

Question 1

Recombinant human granulocyte-colony stimulating factor (rhG-CSF) stimulates the production of neutrophils and may reduce the duration of chemotherapy-induced neutropenia and thereby reduce the incidence of associated sepsis; there is as yet no evidence that it does what?

Answer 1

improves overall survival.

unglycosylated rhG-CSF is Filgrastim.

glycosylated rhG-CSF is lenograstim

Question 2

What are the benefits of pegfilgrastim over filgrastim?

Answer 2

Longer duration of activity

Question 3

In congenital neutropenia, filgrastim has what impact on neutrophil count?

Answer 3

Increases it

Question 4

What is neutropenia?

Answer 4

abnormally low levels of white blood cell: neutrophils.

<1,500 neuts per microliter of blood