GI: Irritable bowel syndrome

Question 1

Alverine citrate, mebeverine and peppermint oil are all what type of drugs?

Answer 1

Antispasmodic drugs (such as alverine citrate, mebeverine hydrochloride and peppermint oil) can be taken in addition to dietary and lifestyle changes.

Question 2

IBS patients who have not responded to laxative from the different classess and who have had constipation for at least how long can be treated with linaclotide?

Answer 2

12 months

Question 3

What type of drug is linaclotide?

Answer 3

Oligo-peptide agonist of guanylate cyclase 2C and remains in the GI tract after it is taken orally. Brand name: Constella.

Question 4

What is the first-line choice of anti-motility drug for relief of diarrhoea?

Answer 4

Diarrhoea

Question 5

A low-dose of what class of antidepressant can be used for abdominal pain or discomfort as a second-line options in patients who have not responded to antispasmodics, anti-motility drugs, or laxatives?

Answer 5

A low-dose tricyclic antidepressant, such as amitriptyline hydrochloride [unlicensed indication], can be used for abdominal pain or discomfort as a second-line option in patients who have not responded to antispasmodics, anti-motility drugs, or laxatives. A selective serotonin reuptake inhibitor may be considered in those who do not respond to a tricyclic antidepressant [unlicensed indication].

Question 6

What type of antidepressant may be considered as a third-line option in patients who have not responded to antispasmodics, anti-motility drugs, laxatives and low-dose tricyclic antidepressant, such as amitriptyline hydrochloride?

Answer 6

An SSRI