Male Infertility Flashcards
1
Q
How can you characterise the causes of azospermia?
A
Obstructive
Non-obstructive
2
Q
What are some obstructive causes of obstructive azospermia?
A
§ Vasectomy § Stricture secondary to infection or instrumentation § Mucous plugging in the CF § Severe varicocele § Chemoradiation
3
Q
Which hormones drive spermatogenesis?
A
FSH, testosterone
4
Q
How do you investigate non-obstructive causes?
A
LH, FSH
Testosterone
SHBG
5
Q
What is the key exam finding for Klinefelters?
A
Testicular volume less than 1ml
6
Q
When do you do a microdisection for sperm?
A
Klinefelters
AZFC gene mutation
7
Q
What are the implications of doing a testes microdisection?
A
Induces failure of that testes - including endocrine function
8
Q
How do you work up male infertility?
A
History
Exam - testicular particular
Karyotype
?Testicular US
