Malabsorption Flashcards
1
Q
Define malabsorption
A
Defective mucosal absorption
2
Q
What is malabsorption caused by
A
Defective luminal digestion
Mucosal disease
Structural disorders
3
Q
What are common causes of malobsorption
A
Crohns disease Coeliac disease Post infectious Biliary obstruction Cirrhosis
4
Q
Uncommon causes of malabsorption
A
Pancreatitis Short bowel syndrome Bacterial overgrowth Drugs Parasites
5
Q
Explain coeliac disease
A
Intestinal antigen presenting cells in people expressing HLADQ2 or HLADQ8 bind with dietary gluten peptides called gliadin to activate mucosal T cells.
6
Q
Coeliac disease mucosal damage characteristcis
A
Villlus atrophy
Crypt hyperplasia
Increased intestinal lymphocytes
7
Q
Coeliac disase symptoms
A
Abdominal pain Bloating Diarrhea Weight loss Failure to thrive Steatorrhoea Malabsorption - vit K deficiency, iron deficiency, calcium deficiency Excess flatus
8
Q
Extra GI manifestations
A
Dermatitis hepatiformis
Decreased fertility
9
Q
Diagnosis
A
IgA anti-transglutaminase test (tTGA)
Biopsy
10
Q
Treatment
A
Gluten free diet
11
Q
Risk Factors
A
Family history
Other Autoimmune conditions
Genetic conditions
