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GI > Malabsorption > Flashcards

Malabsorption Flashcards

1
Q

Autoimmune-mediated intolerance of

gliadin?

A

Celiac disease

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2
Q

Celiac Disease HLA?

A

Dairy Queen on Route 27, 28

HLA-DR2, HLA-DR8

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3
Q

northern European descent, dermatitis herpetiformis, 􏰁bone density?

A

Celiac disease

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4
Q

Dx of Celiac disease?

A

anti-endomysial,
anti-tissue transglutaminase
anti-gliadin antibodies

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5
Q

Bx of Celiac disease?

A

blunting of villi; and lymphocytes in lamina propria

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6
Q

Celiac disease progression?

A

Gliaden=>MHC II=>T cell mediated

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7
Q

If celiac becomes refractory, think?

A

T-cell lymphoma (EATL)

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8
Q

Where does Celiac disease mostly affect?

A

Distal Duodenum

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9
Q

MC Disaccharidase deficiency?

A

Most common is lactase deficiency􏰂=>milk intolerance

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10
Q

Dx of Disaccharidase deficiency?

A

⊕ for lactase deficiency if administration of lactose produces symptoms and serum glucose rises

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11
Q

malabsorption of fat and fat-soluble vitamins (A, D, E, K) as well as vitamin B12 in CF patients?

A

Pancreatic insufficiency

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12
Q

With Pancreatic Insuff., what will happen to your neutral fat content in stool? D-xylose test?

A

Increased neutral stool
d-xylose absorption test: normal urinary
excretion in pancreatic insufficiency

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13
Q

Similar to Celiac Disease in residents of or recent visitors to tropics?

A

Tropical sprue

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14
Q

In what other patients can you see Pancreatic Insuff?

A

obstructing cancer, chronic pancreatitis.

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15
Q

Foamy macrophages in intestinal lamina propria?

A

WHipple’s Disease

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16
Q

What symptoms do you see in WHipple’s Disease?

A

Cardiac symptoms, Arthralgias, and Neurologic symptoms are common

Foamy Whipped cream in a CAN.

17
Q

Who does WHipple’s Disease most common affect?

A

Older Men

18
Q

Whipple’s Disease is caused by? and positive for?

A

Tropheryma whipplei (gram positive); PAS ⊕

GI (20 decks)

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