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GI > GI Pharmacology > Flashcards

GI Pharmacology Flashcards

1
Q

Cimetidine MOA, AE?

A

MOA: Competitive inhibition of H2AE: CYP 450 Inhibitor=>Antiandrogenic effects, confusion

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2
Q

Omeprazole DOC? MOA? AE?

A

MOA: Irreversibly inhibits H+/K+ ATPase in stomach parietal cellsUse: DOC for Peptic Ulcer, gastritis, ZES, RefluxAE: Increased risk of C diff infection and

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3
Q

Bismuth/Sucralfate MOA? What is Bismuth mainly used for? What is unique about Sucralfate? AE? of bismuth

A

MOA: Binds to Ulcer base and protects it from further acid damageBismuth=>4 drug combo for H pyloriAE: Black tongueSucralfate=>prodrug that converts with acid (don’t use with antacids)

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4
Q

Misoprostol MOA? Use? AE?

A

MOA: PGE1 analog=>increases mucus secretionUse: Prevention of NSAID induced ulcersAE: abortion pill; don’t give it to pregos

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5
Q

Ocretotide MOA? Use?

A

MOA: Somatostatin analogUse: DOC for Acute variceal bleeds, Aromegaly, VIPoma, carcinoid tumors

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6
Q

Antacids affect weak bases in what way? weak acids? TCAs?

A

Increase absorption of weak basesDecreases absorption of weak acids and TCAs

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7
Q

AE of Aluminum hydroxide antacid? Magnesium hydroxide antacid? Calcium Carbonate?

A

AluMINIMUM amount of fecesCC=>Chelates!Mg=> Must Go to the bathroom

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8
Q

What is lactulose used for? MOA? AE?

A

DOC=>Hepatic encephalopathy=>promotes nitrogen excretion as NH4 by lowering the pH of the bowelAE: bloating like lactose

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9
Q

Sulfasalazine/Mesalamine MOA? Use? AE?

A

MOA: delivers 5-ASA to the entire bowelUse: DOC for initial Crohns/UCAE: Rash, hemolysis and renal tox (sulfasalazine)

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10
Q

Ondansetron (-Setron) MOA? Use? AE?

A

MOA: 5-HT3 antagonistUse: Antivomiting in patients with chemo (esp. Cisplatin)AE: QT interval prolongation

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11
Q

Metoclopramide+ (-azine)

A

MOA: D2 receptor antagonist=>increases motility and LES toneAE: EPS

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12
Q

Orlistat MOA? Use? AE?

A

MOA: inhibits Gastric and pancreatic lipase=>decreases breakdownUse: Weight LossAE: Steatorrhea, and decreased absorption of fat soluble vitamins

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13
Q

3 drug regimen for H pylori? 4 drug regimen?

A

PPI, Clarithromycin and AmoxicillinPPI, Bismuth, Tetracycline and metronidazole

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14
Q

If Ocretide does not work, what procedure can you do to stop acute variceal bleeding?

A

endoscopic band ligation

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GI (20 decks)

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