IBD/IBS

Question 1

Crohns occurs at which portion of GI tract and what kind of lesions does it create? Does it affect the Rectum?

Answer 1

Any portion of the GI tract, usually the terminal ileum and colon.

Skip lesions, rectal sparing

Question 2

Does UC affect the Rectum?

Answer 2

always with rectal involvement.

Question 3

Crohns is what kind of inflammation?

Answer 3

Transmural inflammation=>fistulas

Question 4

What three main gross morphology do you see in Crohns?

Answer 4

Cobblestone mucosa, Creeping fat, Colon wall thickening (string sign)

Question 5

UC is what kind of inflammation?

Answer 5

submucosal inflammation only

Question 6

What two main gross morphology do you see in UC?

Answer 6

Friable (easily crumbled) mucosal pseudopolyps and Loss of haustra=>lead pipe appearance

Question 7

On microscopy, what do you see in Crohns (1st)?

Answer 7

Noncaseating granulomas and lymphoid aggregates (Th1 mediated)

Question 8

On microscopy, what do you see in UC (2 words)?

Answer 8

Crypt abscesses and no granulomas (Th2 mediated).

Question 9

What are 3 main complications you see in Crohns disease?

Answer 9

Strictures, Fistulas, Gallstones

Question 10

Which one always has blood diarrhea?

Answer 10

UC

Question 11

What are 2 main complications you see in UC disease?

Answer 11

1. toxic megacolon

2. PSC

Question 12

Dave has UC what can I tell him about the CRC involvement in UC. What two things does it depend on?

Answer 12

1. Extent of Colonic Involvement

2. Duration of the disease

Question 13

What is the extraintestinal manifestations of Crohns?

Answer 13

Crohns=>tissue damage=>increased oxalate absorption=>Calcium oxalate stones

Question 14

Tx for Crohns?

Answer 14

Corticosteriods+other immunosuppressants

Question 15

Tx for UC?

Answer 15

5-ASA mesalamine+other immunosuppressants

Question 16

UC causes pseudopolyps therefore, UCs have what kind of ANCA

Answer 16

p-ANCA

Question 17

Does Smoking Protect in UC?

Answer 17

Smoking Protects

Question 18

Mnemonic for UC=> ULCCCERS?

Answer 18

Ulcers
Large intestine
Continuous, Colorectal carcinoma, Crypt
abscesses
Extends proximally Red diarrhea Sclerosing cholangitis

Question 19

Mnemonic for Crohns=>

Answer 19

Think of a granny

Question 20

A middle-aged women with abd pain that Pain improves with defecation, Change in stool frequency, Change in appearance of stool

Answer 20

IBS