making a neuron

Question 1

what is proneural cluster?

Answer 1

group of cells in neuroectoderm in which one cell will become a neuroblast

Question 2

what are cell fates in proneural cluster?

Answer 2

primary - neuroblast

secondary epidermis

Question 3

what is laeral inhibition?

Answer 3

mechanism in which cells inhibit neighbouring cells from developing in a similar way to themselves

Question 4

what group is proneural cluster?

Answer 4

equivelence group (all cells have equilvalent potential to become epidermis/neuroblast)

Question 5

what happes to proneural cluster in notch or delta mutation?

Answer 5

all cell in proneural cluster become neuroblast

Question 6

what are notch and delta?

Answer 6

delta - ligand
notch - receptor
work in same pathway as a ligand receptor pair
membrane bound
signal JUXACRINE (when cels are next to each other )

Question 7

what happens when delta bind to notch?

Answer 7

notch has cleavage which releases intracellular fragment that forms part of transcription complex

Question 8

what do notch and delta cause lateral inhibition

Answer 8

expression of notch causes repression of delta in same cell
amplification of delta and ntoch inhibition
high delta = neuroblast
HIGH DELTA FORMS A NEUROBLAST

Question 9

what fo nueroblast form?

Answer 9

another neuroblast and a ganglion mother cell

assymetric division by autonomous mechanism (numb unevenly distributed

Question 10

what does ganglion mother cell divide into?

Answer 10

2 neurons eventually

Question 11

wha does numb prtein do?

Answer 11

inhibit notch function

Question 12

what happened if over + underexpression of notch in fly?

Answer 12

underexpression - 4 neurons from

overexpression - 4 socket cells form

Question 13

how are nural connections refined?

Answer 13

by pruning / cell death