hox genes and segmentation

Question 1

what is somite?

Answer 1

mesodermal repeating segment of tissue

Question 2

what does recessive mutation in UBX cause?

Answer 2

transformation of 3rd thoracic segment to 2nd (4 wings)

Question 3

what is homeotic transformation?

Answer 3

where one structure of body is replaced by another (still same number of segments)

Question 4

what does ubx regulate?

Answer 4

developmental programme followed by T3 cells

control/selector gene to specify haltere identity

Question 5

what hapens to cells of haltere lacking ubx?

Answer 5

they autonomously form into a wing

Question 6

what are genes/sections in ubx complex (BX-C)?

Answer 6

Ubx, AdbA , Adb B

Question 7

what does each Bx-C contain?

Answer 7

homeobox (180 nucleotide motif)

Question 8

what does homeobox code for?

Answer 8

homeodomain - sequence specific DNA binding motif

Question 9

what do BX-C genes combine with?

Answer 9

HOX genes

Question 10

where is antennapedia gene expressed?

Answer 10

in T2 segment, controls T2 identity

Question 11

what do dominant mutations of antennapedia do?

Answer 11

cause formation of leg instead of antannae

Question 12

what does dominant mutations in hox d13 cause?

Answer 12

synpolydactyly in humans

Question 13

what genes do ANT-C contain?

Answer 13

homeobox genes

Question 14

how are HOX genes expressed along axis/

Answer 14

spatially restricted

Question 15

what is HOX genes protein product?

Answer 15

transcription factor