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Pharmaceutics > Making a Medicine > Flashcards

Making a Medicine Flashcards

1
Q

What is a medicine?

A

Preparation of a substance used to treat or prevent a disease

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2
Q

What is a drug?

A

Substance that exerts the desired pharmacological effect

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3
Q

What are the inactive ingredients called?

A

Excipients

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4
Q

What is preparation known as?

A

Formulation

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5
Q

What is dosage form?

A

Physical form of preparation

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6
Q

What is preformulation?

A

Stage where physiochemical properties of a drug is determined

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7
Q

What is Lipinski’s rule of 5?

A

molecular weight <500
logP <5
H-bond donors <5
H-bond acceptors <10

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8
Q

What does Lipinski’s rule of 5 assume?

A

Absorption by diffusion, excluding substrates for transporters

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9
Q

What is solubility?

A

The max amount of solute that can be dissolved in a given solvent

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10
Q

What is solubility affected by?

A

Solvent properties
Solute properties
Temperature
Pressure

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11
Q

What is the solubility + permeability for class 1 drugs?

A

High

High

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12
Q

What is the solubility + permeability for class 2 drugs?

A

Low

High

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13
Q

What is the solubility + permeability for class 3 drugs?

A

High

Low

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14
Q

What is the solubility + permeability for class 4 drugs?

A

Low

Low

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15
Q

What does logP indicate?

A

How lipophilic the drug is

= lowers aq solubility

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16
Q

Why is logP important?

A

Key determinant of dug absorption + permeability across biological membranes

17
Q

What is the major consideration in formulation choice?

A

Emulsion vs Aq

18
Q

What do many drugs ionise in?

A

H2O

19
Q

What do basic drugs ionise in?

A

More acidic medium

20
Q

What do acidic drugs ionise in?

A

More basic medium

21
Q

What is the ionised form more?

A

Soluble in H2O

Pharmaceutics (21 decks)

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