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Pharmaceutics > Preformulation - Compaction > Flashcards

Preformulation - Compaction Flashcards

1
Q

What is compression?

A

Particles forced into small space, reducing porosity + vol

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2
Q

What is compressibility?

A

Amenability to compression

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3
Q

What is compaction?

A

Particles cohere to form a solid specimen of defined geometry

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4
Q

What is compactability?

A

Susceptibility to compaction

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5
Q

Are compaction + compression the same?

A

NO

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6
Q

What does compaction require?

A

Compression

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7
Q

Will compression always result in compaction?

A

NO

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8
Q

How can particle cohesion be modified?

A

By formulation

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9
Q

What are the stages of the compaction cycle?

A

Filling
Compression
Ejection

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10
Q

Describe filling in compaction cycle

A

Lower punch inserted partially into die then powder filled into die cavity
Lower punch prevents powder falling out
Pusher removes any excess

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11
Q

Describe compression in compaction cycle

A

Upper punch inserts into die cavity
Upper punch moves down + lower punch moves up to compress tablet
Both punches move up

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12
Q

What is the Heckel equation?

A

ln (1/e) = kP + a

e = porosity 
P = compression pressure
K = constant relating to particle deformation
A = constant relating to particle rearrangement + fragmentation
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13
Q

What is tensile strength a result of?

A

Inter-particle bonding within the tablet

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14
Q

How is tensile strength determined?

A

Using diametric compression test

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15
Q

What happens if the tensile strength is too high?

A

Tablet may not dissolve

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16
Q

What happens if the tensile strength is too low?

A

May break in packing = cannot be used

17
Q

What does it mean the greater the tensile strength?

A

More resistant the tablet is too crushing

18
Q

How do you calculate tensile strength of disc-shaped, flat-faced tablet?

A

2F/ πdh

F = tablet fracture force
d = tablet diameter
h = tablet thickness
19
Q

What is the tensile strength of flat/overly convex tablets?

A

Low

Pharmaceutics (21 decks)

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