Major Histocompatibility Complex Flashcards
in adaptive immune system for appropriate response to a foreign antigen…
lymphocytes must recog antigen be stimulated to divide and differentiate
on b cells what is antigen recognition mediated by
surface immunoglobulins
on T cells what is antigen recognition mediated by
T cell receptor
what do t cells recognise
parts of antigens that are expressed on cell surfaces
where might antigens come from
from pathogens that replicate within host cells (viruses)
may come from pathogens or their products that have been endocytosed from the extracellular fluid
what si detected by t cells
presence of t cells and foreign antigens
what are major histiocompatibilty complex molecules
pathogen derived peptides delivered to and presented at cell surface by specialised glycoproteins
where are MHC proteins encoded in
large cluster of genes on chromosome 6
what are recognised by recipient immune system in transplantation
MHC antigens
in humans what are MHC molecules referred to as
HLA
human leucocyte antigens
what ar the two classes of MHC family
class 1 n 2
what does class 1 consist of
HLA - A
HLA - B
HLA - C
what does class 2 consist of
HLA - DP
HLA - DQ
HLA - DR
what does both classes have in common
similar 3d structures
where is class 1 expressed
on all nucleated cells including leucocytes
