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BLISS > Lymphomas > Flashcards

Lymphomas Flashcards

1
Q

Lymphoid neoplasms include what?

A

Hodgkins, non-Hodgkins, plasma cell dyscrasias and some leukemias

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2
Q

Leukemia vs lymphoma

A

leukemias = blood and bone marrow

lymphomas = lymph nodes or tissues

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3
Q

Hodgkin vs non-Hodgkin

A

Hodgkin = presents with RS cells

Non Hodgkin - no RS cells

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4
Q

How to diagnose lymphoid neoplasms

A

Immunohistochemistry, flow cytometry, genotype/karotype

Antibodys, cell markers (CD markers)

Morphology of cells

Maturation levels

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5
Q

Most common leukemias in adults

A

CLL

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6
Q

Most common indolent NHL in the US?

A

Follicular lymphoma

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7
Q

Chromosomal abnormality associated with FCCL

A

T(14;18)

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8
Q

Follicular lymphoma immunophenotype

A

CD20, CD10, BCL6

BCL2 proteins

  • B-cell markers*
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9
Q

Mantle Cell Lymphoma immunophenotype

A

T(11;14)

Cyclin D1 protein

IgM, IgD

CD20 CD5

also show pseudo-polyps

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10
Q

Extranodal Marginal Zone Lymphoma immunophenotype

A

CD20

Surface IgD, IgM

Lymphoepithelial lesions

often presents w/ H. Pylori infections

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11
Q

Diffuse large B cell Lymphoma immunophenotype

A

BCL6 gene rearrangement and point mutations ; 3q27

T(14;18)

BCL2 gene and protein

CD20. CD10

IgM and IgG

  • can present with EBV, KSHV, HHV-8 infections*
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12
Q

Burkett lymphoma immunophenotype

A

T(8;14)

Starry sky pattern

CD10 CD20 IgM

BCL6 proteins

often latently infected with EBV

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13
Q

Hodgkin nodular sclerosis Lymphoma immunophenotype

A

RS cells

Classical

  • CD15/CD30
  • B and T cell antigens

Shows lacunae cells and collagen bands

  • Most common type*
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14
Q

Mixed-Cellularity Hodgkin’s lymphoma immunophenotype

A

Plentiful levels or RS cells, eosinophils, plasma cells and macrophages, small lymphocytes

Classical

  • CD15/CD30
  • B and T cell antigens
  • RS cells often have BBV pathogen in them
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15
Q

Lymphocyte-Rich Hodgkin Lymphoma immunophenotype

A

RS cells

Numerous small lymphocytes

Classical

  • CD15/CD30
  • B and T cell antigens
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16
Q

Lymphocyte depletion Hodgkin Lymphoma immunophenotype

A

Lots of RS cells with almost no other lymphocytes

Classical

  • CD15/CD30
  • B and T cell antigens
17
Q

Lymphocyte-predominant Hodgkins immunophenotype

A

Popcorn cell RS cells

Non-classical

  • B cell markers
  • CD 20
18
Q

Where does Hodgkin lymphoma typically arise?

A

Germinal center B cells

19
Q

Staging of Hodgkin’s lymphoma

A

Stage 1/2 = Younger patients with no B symptoms

Stage 3/4 = older patients with B symptoms, Pruritus and anemia

20
Q

What are B-symptoms?

A

Fever

Weight loss

Night sweats

21
Q

Treatment methods of Hodgkins

A

Radiotherapy

Chemotherapy

Anti-PD-1 antibodies

22
Q

What virus is most commonly associated with Hodgkin’s lymphoma?

A 
Epstein Barr (EBV)
- especially in mixed cellarity subtype

(A lot of RS cells present with EBV in their cytoplasm)

BLISS (42 decks)

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