Lymphomas Flashcards

1
Q

tumor or cancer of blood cells or bone marrow

A

leukemia

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2
Q

cancer that starts in the lymph nodes or lymphatic system

A

lymphoma

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3
Q

produces abnormal white blood cells which inhibits the function of the immune system and platelet function-

A

leukemia

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4
Q

invades other organs by unnecessary and uncontrollable growth of lymphoid tissue

A

lymphoma

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5
Q

have symptoms typical of other cancers and may have no early telling symptoms, especially if chronic

A

leukemia

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6
Q

often present with signs of swollen lymph nodes in the neck, armpits or groin which are frequently painful

A

lymphoma

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7
Q

From what cells do red cells, basophils, neutrophils, monocytes, eosinophils, platelets originate?

A

myeloid cells

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8
Q

From what cells do T lymphocyts, B lymphocytes, NK cells originate

A

lymphocytic cells

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9
Q

Where are most lymphocytes located?

A

lymph nodes, spleen, bone marrow and lymphatic vessels

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10
Q

due to overexpression of BCL-2 (gene that blocks programmed cell death)

A

follicular lymphoma

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11
Q

What is the difference between the incidence of non-Hodgkins lymphoma and hodgkins lymphoma?

A

Hodgkin lymphomas have a bimodal distribution of occurrence whereas non-hodgkin lymphoma increases after age 40

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12
Q

Symptoms include: painless swelling in nodes, fever, night sweats, weight loss, fatigue, itchy skin

A

lymphoma

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13
Q

Subtypes of NHL

A

B and T cell

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14
Q

Common in patients with HIV

A

Burkitt’s Lymphoma

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15
Q

Low Grade (slow growing, incurable) NHLs

A

Follicular, small lymphocytic, Waldenstrom’s

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16
Q

Intermediate Grade (rapid growing, potentially curable) NHLs

A

Diffuse large B cell, mantle cell, anaplastic large (T cell) NHL

17
Q

High Grade (fastest growing, potentially curable) NHLs

A

Burkitt’s lymphoma, lymphoblastic lymphoma

18
Q

differentgiant cellsfound with light microscopy inbiopsiesfrom individuals with Hodgkin’s lymphoma. Usually derived from B lymphocytes

A

Reed-Sternberg cell

19
Q

How are tumors of lymphoma categorized?

A

based on where the tumour is present (Ann Arbor system)

20
Q

New biotherapy for treatment of NHL

A

antibody CD20 (Rituximab)

21
Q

gives indication of degree of cellular breakdown

A

LDH levels

22
Q

Standard therapy for many of the lymphomas

A

CHOP therapy